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Assay Detail

CHEMBL2363377

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Functional
SANGER: Inhibition of human LC-2-ad cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LC-2-ad
Confidence 1 — Organism
Curated By Autocuration

Target

LC-2-ad (CHEMBL2366260) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.86 10.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.19
CHEMBL105 MITOMYCIN 4.0 1 9.60
CHEMBL428647 PACLITAXEL 4.0 1 9.50
CHEMBL413 SIROLIMUS 4.0 1 9.37
CHEMBL325041 BORTEZOMIB 3.0 1 8.96
CHEMBL65 CAMPTOTHECIN -1.0 1 8.55
CHEMBL3545252 DOCETAXEL 4.0 1 8.47
CHEMBL96926 THAPSIGARGIN — 1 8.33
CHEMBL553025 VINORELBINE 4.0 1 8.30
CHEMBL53463 DOXORUBICIN 4.0 1 8.29
CHEMBL159 VINBLASTINE 4.0 1 8.10
CHEMBL513909 BI-2536 2.0 1 7.96
CHEMBL252164 LUMINESPIB 2.0 1 7.86
CHEMBL514499 GW843682X — 1 7.81
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.80
CHEMBL300389 — — 1 7.78
CHEMBL213100 — — 1 7.69
CHEMBL1256459 TORIN1 — 1 7.67
CHEMBL379300 A-443654 — 1 7.66
CHEMBL5416410 DASATINIB 4.0 1 7.59
CHEMBL1972860 ELESCLOMOL 3.0 1 7.56
CHEMBL6067492 BLEOMYCIN 4.0 1 7.09
CHEMBL572878 TOZASERTIB 2.0 1 7.06
CHEMBL608533 MIDOSTAURIN 4.0 1 6.95
CHEMBL401930 — — 1 6.93
CHEMBL109480 TANESPIMYCIN 3.0 1 6.85
CHEMBL1879463 DACTOLISIB 3.0 1 6.80
CHEMBL509032 TAE-684 — 1 6.71
CHEMBL1801204 AZD-8055 1.0 1 6.66
CHEMBL803 CYTARABINE 4.0 1 6.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.06528 nM 10.19
CHEMBL105 MITOMYCIN IC50 = 0.2492 nM 9.60
CHEMBL428647 PACLITAXEL IC50 = 0.3167 nM 9.50
CHEMBL413 SIROLIMUS IC50 = 0.4227 nM 9.37
CHEMBL325041 BORTEZOMIB IC50 = 1.084 nM 8.96
CHEMBL65 CAMPTOTHECIN IC50 = 2.806 nM 8.55
CHEMBL3545252 DOCETAXEL IC50 = 3.403 nM 8.47
CHEMBL96926 THAPSIGARGIN IC50 = 4.64 nM 8.33
CHEMBL553025 VINORELBINE IC50 = 4.977 nM 8.30
CHEMBL53463 DOXORUBICIN IC50 = 5.074 nM 8.29
CHEMBL159 VINBLASTINE IC50 = 7.896 nM 8.10
CHEMBL513909 BI-2536 IC50 = 10.93 nM 7.96
CHEMBL252164 LUMINESPIB IC50 = 13.7 nM 7.86
CHEMBL514499 GW843682X IC50 = 15.61 nM 7.81
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 15.81 nM 7.80
CHEMBL300389 — IC50 = 16.65 nM 7.78
CHEMBL213100 — IC50 = 20.33 nM 7.69
CHEMBL1256459 TORIN1 IC50 = 21.37 nM 7.67
CHEMBL379300 A-443654 IC50 = 22.15 nM 7.66
CHEMBL5416410 DASATINIB IC50 = 25.86 nM 7.59
CHEMBL1972860 ELESCLOMOL IC50 = 27.81 nM 7.56
CHEMBL6067492 BLEOMYCIN IC50 = 80.36 nM 7.09
CHEMBL572878 TOZASERTIB IC50 = 87.89 nM 7.06
CHEMBL608533 MIDOSTAURIN IC50 = 113.45 nM 6.95
CHEMBL401930 — IC50 = 116.58 nM 6.93
CHEMBL109480 TANESPIMYCIN IC50 = 141.21 nM 6.85
CHEMBL1879463 DACTOLISIB IC50 = 158.62 nM 6.80
CHEMBL509032 TAE-684 IC50 = 196.92 nM 6.71
CHEMBL1801204 AZD-8055 IC50 = 220.84 nM 6.66
CHEMBL803 CYTARABINE IC50 = 229.61 nM 6.64
CHEMBL1171837 PONATINIB IC50 = 242.65 nM 6.62
CHEMBL603469 LESTAURTINIB IC50 = 257.21 nM 6.59
CHEMBL575448 BMS-754807 IC50 = 270.37 nM 6.57
CHEMBL449158 BRYOSTATIN 1 IC50 = 338.22 nM 6.47
CHEMBL585951 — IC50 = 349.65 nM 6.46
CHEMBL217354 — IC50 = 424.15 nM 6.37
CHEMBL1201182 TEMSIROLIMUS IC50 = 466.87 nM 6.33
CHEMBL197603 — IC50 = 483.03 nM 6.32
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 537.31 nM 6.27
CHEMBL27759 ENTINOSTAT IC50 = 536.63 nM 6.27
CHEMBL2041933 AZD-7762 IC50 = 565.22 nM 6.25
CHEMBL1242367 — IC50 = 702.05 nM 6.15
CHEMBL591429 PAC-1 IC50 = 898.0 nM 6.05
CHEMBL9470 SHIKONIN IC50 = 952.55 nM 6.02
CHEMBL535 SUNITINIB IC50 = 1114.07 nM 5.95
CHEMBL289228 TIPIFARNIB IC50 = 1488.47 nM 5.83
CHEMBL577784 BX-795 IC50 = 1471.32 nM 5.83
CHEMBL1091644 LINSITINIB IC50 = 1738.87 nM 5.76
CHEMBL1190711 — IC50 = 1822.38 nM 5.74
CHEMBL44657 ETOPOSIDE IC50 = 2064.07 nM 5.68