Assay Detail
Functional
CHEMBL2363403
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SANGER: Inhibition of human MC116 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MC116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.70 | 10.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.61 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 9.01 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.54 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.41 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.10 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.81 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.80 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.59 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.57 |
| CHEMBL514499 | GW843682X | — | 1 | 7.44 |
| CHEMBL300389 | — | — | 1 | 7.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.24 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.22 |
| CHEMBL512504 | — | — | 1 | 7.00 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.95 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.94 |
| CHEMBL379300 | A-443654 | — | 1 | 6.86 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.83 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.79 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.72 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.59 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.55 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.47 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.41 |
| CHEMBL585951 | — | — | 1 | 6.39 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.32 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.15 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.14 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.07 |
| CHEMBL197603 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.02451 | nM | 10.61 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 0.9847 | nM | 9.01 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.888 | nM | 8.54 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.865 | nM | 8.41 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.953 | nM | 8.10 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 15.54 | nM | 7.81 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 15.86 | nM | 7.80 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 25.53 | nM | 7.59 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL514499 | GW843682X | IC50 | = | 36.36 | nM | 7.44 |
| CHEMBL300389 | — | IC50 | = | 40.66 | nM | 7.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 57.8 | nM | 7.24 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 60.61 | nM | 7.22 |
| CHEMBL512504 | — | IC50 | = | 100.14 | nM | 7.00 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 113.37 | nM | 6.95 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 114.1 | nM | 6.94 |
| CHEMBL379300 | A-443654 | IC50 | = | 137.46 | nM | 6.86 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 148.85 | nM | 6.83 |
| CHEMBL513909 | BI-2536 | IC50 | = | 161.58 | nM | 6.79 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 189.64 | nM | 6.72 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 256.54 | nM | 6.59 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 283.09 | nM | 6.55 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 335.31 | nM | 6.47 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 391.41 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 410.68 | nM | 6.39 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 481.66 | nM | 6.32 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 709.33 | nM | 6.15 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 715.81 | nM | 6.14 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 850.11 | nM | 6.07 |
| CHEMBL197603 | — | IC50 | = | 856.45 | nM | 6.07 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1136.21 | nM | 5.95 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1212.28 | nM | 5.92 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1283.49 | nM | 5.89 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1416.64 | nM | 5.85 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1436.15 | nM | 5.84 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1461.22 | nM | 5.83 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1598.79 | nM | 5.80 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1786.36 | nM | 5.75 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2110.53 | nM | 5.68 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 2363.97 | nM | 5.63 |
| CHEMBL1190711 | — | IC50 | = | 2511.37 | nM | 5.60 |
| CHEMBL221137 | EMBELIN | IC50 | = | 2818.15 | nM | 5.55 |
| CHEMBL213100 | — | IC50 | = | 2857.04 | nM | 5.54 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 3111.12 | nM | 5.51 |
| CHEMBL191384 | — | IC50 | = | 3169.59 | nM | 5.50 |
| CHEMBL2363137 | — | IC50 | = | 3138.53 | nM | 5.50 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 3620.49 | nM | 5.44 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3954.89 | nM | 5.40 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4032.57 | nM | 5.39 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4430.81 | nM | 5.35 |