Assay Detail
Functional
CHEMBL2363404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human MCF7 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.74 | 10.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.06 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.88 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.80 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.79 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.47 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.19 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.93 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.86 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.50 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.50 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.31 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.29 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.03 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.01 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.78 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.48 |
| CHEMBL217354 | — | — | 1 | 6.47 |
| CHEMBL585951 | — | — | 1 | 6.41 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.39 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.36 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.24 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.08 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.05 |
| CHEMBL1190711 | — | — | 1 | 5.94 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.93 |
| CHEMBL191384 | — | — | 1 | 5.82 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.74 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.08657 | nM | 10.06 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1314 | nM | 9.88 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.1359 | nM | 9.87 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1.589 | nM | 8.80 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.608 | nM | 8.79 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 3.349 | nM | 8.47 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.011 | nM | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.427 | nM | 8.19 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 11.65 | nM | 7.93 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 31.36 | nM | 7.50 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 48.58 | nM | 7.31 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 50.79 | nM | 7.29 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 92.99 | nM | 7.03 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 96.77 | nM | 7.01 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 166.3 | nM | 6.78 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 332.74 | nM | 6.48 |
| CHEMBL217354 | — | IC50 | = | 336.9 | nM | 6.47 |
| CHEMBL585951 | — | IC50 | = | 389.32 | nM | 6.41 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 405.3 | nM | 6.39 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 434.85 | nM | 6.36 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 569.69 | nM | 6.24 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 830.5 | nM | 6.08 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 898.59 | nM | 6.05 |
| CHEMBL1190711 | — | IC50 | = | 1147.84 | nM | 5.94 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1165.84 | nM | 5.93 |
| CHEMBL191384 | — | IC50 | = | 1502.4 | nM | 5.82 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1817.8 | nM | 5.74 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2002.48 | nM | 5.70 |
| CHEMBL472940 | — | IC50 | = | 2180.7 | nM | 5.66 |
| CHEMBL259181 | — | IC50 | = | 2256.28 | nM | 5.65 |
| CHEMBL2363137 | — | IC50 | = | 2639.34 | nM | 5.58 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2714.64 | nM | 5.57 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2861.17 | nM | 5.54 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3200.5 | nM | 5.50 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3351.44 | nM | 5.47 |
| CHEMBL255342 | — | IC50 | = | 3859.15 | nM | 5.41 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3857.95 | nM | 5.41 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5007.38 | nM | 5.30 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 5145.17 | nM | 5.29 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 5442.44 | nM | 5.26 |
| CHEMBL379975 | — | IC50 | = | 5994.05 | nM | 5.22 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 8029.22 | nM | 5.09 |
| CHEMBL221137 | EMBELIN | IC50 | = | 8346.36 | nM | 5.08 |
| CHEMBL393929 | — | IC50 | = | 11184.92 | nM | 4.95 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 11812.64 | nM | 4.93 |
| CHEMBL189584 | PD-173074 | IC50 | = | 11616.74 | nM | 4.93 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 13236.46 | nM | 4.88 |
| CHEMBL1186585 | — | IC50 | = | 14761.23 | nM | 4.83 |