Assay Detail
Functional
CHEMBL2363408
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SANGER: Inhibition of human MDA-MB-231 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.47 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.25 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.72 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.61 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.56 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.43 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.35 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.04 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.98 |
| CHEMBL217354 | — | — | 1 | 6.97 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.79 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.64 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.56 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.55 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.23 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.19 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.17 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.10 |
| CHEMBL585951 | — | — | 1 | 6.01 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.99 |
| CHEMBL3349342 | — | — | 1 | 5.95 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.82 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.79 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.76 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.60 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.58 |
| CHEMBL399530 | — | — | 1 | 5.55 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.49 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.42 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.5573 | nM | 9.25 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 19.04 | nM | 7.72 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 24.61 | nM | 7.61 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 27.78 | nM | 7.56 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 37.39 | nM | 7.43 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 44.59 | nM | 7.35 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 90.82 | nM | 7.04 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 105.06 | nM | 6.98 |
| CHEMBL217354 | — | IC50 | = | 108.07 | nM | 6.97 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 161.52 | nM | 6.79 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 229.98 | nM | 6.64 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 273.07 | nM | 6.56 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 281.01 | nM | 6.55 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 585.88 | nM | 6.23 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 652.03 | nM | 6.19 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 683.39 | nM | 6.17 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 801.31 | nM | 6.10 |
| CHEMBL585951 | — | IC50 | = | 966.67 | nM | 6.01 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1015.44 | nM | 5.99 |
| CHEMBL3349342 | — | IC50 | = | 1122.39 | nM | 5.95 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1530.55 | nM | 5.82 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1603.8 | nM | 5.79 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1719.93 | nM | 5.76 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2495.72 | nM | 5.60 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2614.19 | nM | 5.58 |
| CHEMBL399530 | — | IC50 | = | 2803.8 | nM | 5.55 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 3239.64 | nM | 5.49 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 3819.51 | nM | 5.42 |
| CHEMBL105442 | CI-1040 | IC50 | = | 4292.23 | nM | 5.37 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 4558.99 | nM | 5.34 |
| CHEMBL573107 | — | IC50 | = | 4721.15 | nM | 5.33 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4702.43 | nM | 5.33 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 5565.23 | nM | 5.25 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5827.32 | nM | 5.24 |
| CHEMBL379975 | — | IC50 | = | 6857.26 | nM | 5.16 |
| CHEMBL577784 | BX-795 | IC50 | = | 8238.05 | nM | 5.08 |
| CHEMBL803 | CYTARABINE | IC50 | = | 8823.83 | nM | 5.05 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9086.45 | nM | 5.04 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 10211.44 | nM | 4.99 |
| CHEMBL191384 | — | IC50 | = | 12306.85 | nM | 4.91 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 13773.78 | nM | 4.86 |
| CHEMBL2363137 | — | IC50 | = | 14340.29 | nM | 4.84 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 16713.65 | nM | 4.78 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 18650.2 | nM | 4.73 |
| CHEMBL221137 | EMBELIN | IC50 | = | 21822.01 | nM | 4.66 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 22897.96 | nM | 4.64 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 28279.47 | nM | 4.55 |
| CHEMBL202721 | — | IC50 | = | 28485.07 | nM | 4.54 |
| CHEMBL477989 | SB590885 | IC50 | = | 29602.77 | nM | 4.53 |