Assay Detail
Functional
CHEMBL2363424
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SANGER: Inhibition of human MHH-ES-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MHH-ES-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.86 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.89 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.15 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.05 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.41 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.38 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.29 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.24 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.90 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.79 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.67 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 7.36 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.28 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.04 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.97 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.73 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.63 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.60 |
| CHEMBL585951 | — | — | 1 | 6.56 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.49 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.49 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.40 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.33 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 6.30 |
| CHEMBL217354 | — | — | 1 | 6.30 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.16 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.08 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.93 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.05311 | nM | 10.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.1293 | nM | 9.89 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.6999 | nM | 9.15 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.893 | nM | 9.05 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.894 | nM | 8.41 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.184 | nM | 8.38 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5.692 | nM | 8.24 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.63 | nM | 7.90 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 16.26 | nM | 7.79 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 21.58 | nM | 7.67 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 43.57 | nM | 7.36 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 51.95 | nM | 7.28 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 91.9 | nM | 7.04 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 107.01 | nM | 6.97 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 122.06 | nM | 6.91 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 186.29 | nM | 6.73 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 236.81 | nM | 6.63 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 249.4 | nM | 6.60 |
| CHEMBL585951 | — | IC50 | = | 274.32 | nM | 6.56 |
| CHEMBL803 | CYTARABINE | IC50 | = | 323.38 | nM | 6.49 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 320.85 | nM | 6.49 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 395.88 | nM | 6.40 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 462.71 | nM | 6.33 |
| CHEMBL217354 | — | IC50 | = | 500.39 | nM | 6.30 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 500.56 | nM | 6.30 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 688.56 | nM | 6.16 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 834.57 | nM | 6.08 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1179.86 | nM | 5.93 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1620.67 | nM | 5.79 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1704.35 | nM | 5.77 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1795.68 | nM | 5.75 |
| CHEMBL202721 | — | IC50 | = | 2129.51 | nM | 5.67 |
| CHEMBL577784 | BX-795 | IC50 | = | 2726.33 | nM | 5.56 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 4045.45 | nM | 5.39 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4624.11 | nM | 5.33 |
| CHEMBL573107 | — | IC50 | = | 4825.04 | nM | 5.32 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 4810.86 | nM | 5.32 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 5169.25 | nM | 5.29 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5265.04 | nM | 5.28 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 5599.07 | nM | 5.25 |
| CHEMBL2363137 | — | IC50 | = | 6432.16 | nM | 5.19 |
| CHEMBL258844 | — | IC50 | = | 6884.3 | nM | 5.16 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 7077.62 | nM | 5.15 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 7827.49 | nM | 5.11 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 8518.34 | nM | 5.07 |
| CHEMBL1186585 | — | IC50 | = | 10971.48 | nM | 4.96 |
| CHEMBL1190711 | — | IC50 | = | 11020.04 | nM | 4.96 |
| CHEMBL399530 | — | IC50 | = | 10934.94 | nM | 4.96 |
| CHEMBL191384 | — | IC50 | = | 11843.64 | nM | 4.93 |