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Assay Detail

CHEMBL2363445

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Functional
SANGER: Inhibition of human MZ1-PC cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MZ1-PC
Confidence 1 — Organism
Curated By Autocuration

Target

MZ1-PC (CHEMBL2366204) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.76 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 9.82
CHEMBL94657 PATUPILONE 3.0 1 9.22
CHEMBL428647 PACLITAXEL 4.0 1 9.14
CHEMBL3545252 DOCETAXEL 4.0 1 8.93
CHEMBL325041 BORTEZOMIB 3.0 1 8.45
CHEMBL553025 VINORELBINE 4.0 1 7.75
CHEMBL9470 SHIKONIN — 1 7.71
CHEMBL65 CAMPTOTHECIN -1.0 1 7.69
CHEMBL514499 GW843682X — 1 7.65
CHEMBL53463 DOXORUBICIN 4.0 1 7.62
CHEMBL159 VINBLASTINE 4.0 1 7.62
CHEMBL252164 LUMINESPIB 2.0 1 7.58
CHEMBL5416410 DASATINIB 4.0 1 7.51
CHEMBL513909 BI-2536 2.0 1 7.38
CHEMBL300389 — — 1 7.37
CHEMBL1256459 TORIN1 — 1 7.18
CHEMBL379300 A-443654 — 1 7.10
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.96
CHEMBL1171837 PONATINIB 4.0 1 6.95
CHEMBL1972860 ELESCLOMOL 3.0 1 6.84
CHEMBL509032 TAE-684 — 1 6.75
CHEMBL585951 — — 1 6.71
CHEMBL1879463 DACTOLISIB 3.0 1 6.69
CHEMBL575448 BMS-754807 2.0 1 6.67
CHEMBL6067492 BLEOMYCIN 4.0 1 6.65
CHEMBL213100 — — 1 6.64
CHEMBL888 GEMCITABINE 4.0 1 6.59
CHEMBL2144069 — — 1 6.55
CHEMBL507361 MIRDAMETINIB 2.0 1 6.43
CHEMBL608533 MIDOSTAURIN 4.0 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 0.1521 nM 9.82
CHEMBL94657 PATUPILONE IC50 = 0.6069 nM 9.22
CHEMBL428647 PACLITAXEL IC50 = 0.7294 nM 9.14
CHEMBL3545252 DOCETAXEL IC50 = 1.18 nM 8.93
CHEMBL325041 BORTEZOMIB IC50 = 3.536 nM 8.45
CHEMBL553025 VINORELBINE IC50 = 17.7 nM 7.75
CHEMBL9470 SHIKONIN IC50 = 19.28 nM 7.71
CHEMBL65 CAMPTOTHECIN IC50 = 20.33 nM 7.69
CHEMBL514499 GW843682X IC50 = 22.21 nM 7.65
CHEMBL53463 DOXORUBICIN IC50 = 23.81 nM 7.62
CHEMBL159 VINBLASTINE IC50 = 24.19 nM 7.62
CHEMBL252164 LUMINESPIB IC50 = 26.39 nM 7.58
CHEMBL5416410 DASATINIB IC50 = 31.19 nM 7.51
CHEMBL513909 BI-2536 IC50 = 41.27 nM 7.38
CHEMBL300389 — IC50 = 42.7 nM 7.37
CHEMBL1256459 TORIN1 IC50 = 65.98 nM 7.18
CHEMBL379300 A-443654 IC50 = 79.54 nM 7.10
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 108.3 nM 6.96
CHEMBL1171837 PONATINIB IC50 = 113.36 nM 6.95
CHEMBL1972860 ELESCLOMOL IC50 = 143.79 nM 6.84
CHEMBL509032 TAE-684 IC50 = 178.35 nM 6.75
CHEMBL585951 — IC50 = 194.67 nM 6.71
CHEMBL1879463 DACTOLISIB IC50 = 205.58 nM 6.69
CHEMBL575448 BMS-754807 IC50 = 215.84 nM 6.67
CHEMBL6067492 BLEOMYCIN IC50 = 224.34 nM 6.65
CHEMBL213100 — IC50 = 227.16 nM 6.64
CHEMBL888 GEMCITABINE IC50 = 254.35 nM 6.59
CHEMBL2144069 — IC50 = 279.99 nM 6.55
CHEMBL507361 MIRDAMETINIB IC50 = 368.81 nM 6.43
CHEMBL608533 MIDOSTAURIN IC50 = 417.83 nM 6.38
CHEMBL105 MITOMYCIN IC50 = 450.11 nM 6.35
CHEMBL449158 BRYOSTATIN 1 IC50 = 553.77 nM 6.26
CHEMBL197603 — IC50 = 595.15 nM 6.22
CHEMBL217354 — IC50 = 634.91 nM 6.20
CHEMBL401930 — IC50 = 763.84 nM 6.12
CHEMBL44657 ETOPOSIDE IC50 = 811.1 nM 6.09
CHEMBL3349342 — IC50 = 1341.74 nM 5.87
CHEMBL1084546 PF-00562271 IC50 = 1623.12 nM 5.79
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1631.64 nM 5.79
CHEMBL803 CYTARABINE IC50 = 1803.38 nM 5.74
CHEMBL217092 SARACATINIB IC50 = 2293.56 nM 5.64
CHEMBL289228 TIPIFARNIB IC50 = 2824.59 nM 5.55
CHEMBL515416 — IC50 = 2917.27 nM 5.54
CHEMBL413 SIROLIMUS IC50 = 3090.78 nM 5.51
CHEMBL483847 — IC50 = 3208.73 nM 5.49
CHEMBL1614701 SELUMETINIB IC50 = 3316.05 nM 5.48
CHEMBL1336 SORAFENIB IC50 = 3475.09 nM 5.46
CHEMBL1190711 — IC50 = 3485.83 nM 5.46
CHEMBL2041933 AZD-7762 IC50 = 3579.86 nM 5.45
CHEMBL27759 ENTINOSTAT IC50 = 3616.24 nM 5.44