Assay Detail
Functional
CHEMBL2363458
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SANGER: Inhibition of human NB6 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NB6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.41 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.34 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.07 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.76 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.40 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.28 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.10 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.90 |
| CHEMBL514499 | GW843682X | — | 1 | 6.85 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.81 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.74 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.73 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.40 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.34 |
| CHEMBL379300 | A-443654 | — | 1 | 6.32 |
| CHEMBL220241 | GSK-269962A | — | 1 | 6.23 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.20 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.17 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.11 |
| CHEMBL585951 | — | — | 1 | 6.04 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.03 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.01 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.99 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.93 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.84 |
| CHEMBL213100 | — | — | 1 | 5.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.66 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.65 |
| CHEMBL300389 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4.576 | nM | 8.34 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 8.476 | nM | 8.07 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 17.54 | nM | 7.76 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 39.52 | nM | 7.40 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 52.71 | nM | 7.28 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 80.02 | nM | 7.10 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 125.68 | nM | 6.90 |
| CHEMBL514499 | GW843682X | IC50 | = | 141.73 | nM | 6.85 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 142.32 | nM | 6.85 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 156.23 | nM | 6.81 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 182.71 | nM | 6.74 |
| CHEMBL513909 | BI-2536 | IC50 | = | 185.66 | nM | 6.73 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 396.66 | nM | 6.40 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 454.4 | nM | 6.34 |
| CHEMBL379300 | A-443654 | IC50 | = | 479.75 | nM | 6.32 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 591.14 | nM | 6.23 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 627.71 | nM | 6.20 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 673.35 | nM | 6.17 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 772.54 | nM | 6.11 |
| CHEMBL585951 | — | IC50 | = | 911.67 | nM | 6.04 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 935.83 | nM | 6.03 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 984.62 | nM | 6.01 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1031.09 | nM | 5.99 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1180.22 | nM | 5.93 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1444.6 | nM | 5.84 |
| CHEMBL213100 | — | IC50 | = | 1696.98 | nM | 5.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1912.98 | nM | 5.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2185.0 | nM | 5.66 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2233.52 | nM | 5.65 |
| CHEMBL300389 | — | IC50 | = | 2324.93 | nM | 5.63 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2403.74 | nM | 5.62 |
| CHEMBL573107 | — | IC50 | = | 2457.79 | nM | 5.61 |
| CHEMBL217354 | — | IC50 | = | 2485.9 | nM | 5.61 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2482.8 | nM | 5.61 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2623.28 | nM | 5.58 |
| CHEMBL577784 | BX-795 | IC50 | = | 2736.28 | nM | 5.56 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 2943.81 | nM | 5.53 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 3182.59 | nM | 5.50 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 3281.9 | nM | 5.48 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3555.63 | nM | 5.45 |
| CHEMBL472940 | — | IC50 | = | 3837.51 | nM | 5.42 |
| CHEMBL379975 | — | IC50 | = | 3895.46 | nM | 5.41 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3914.75 | nM | 5.41 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4425.09 | nM | 5.35 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4862.04 | nM | 5.31 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 6296.22 | nM | 5.20 |
| CHEMBL509032 | TAE-684 | IC50 | = | 7548.99 | nM | 5.12 |
| CHEMBL202721 | — | IC50 | = | 8487.43 | nM | 5.07 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 9760.29 | nM | 5.01 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 9922.59 | nM | 5.00 |