Assay Detail
Functional
CHEMBL2363489
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SANGER: Inhibition of human NCI-H1770 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1770 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.51 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.04 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.70 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.47 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.26 |
| CHEMBL188678 | — | — | 1 | 7.67 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.59 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.55 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.33 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.26 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.23 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.99 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.99 |
| CHEMBL512504 | — | — | 1 | 6.96 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.91 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.88 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.63 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.61 |
| CHEMBL102714 | SB-216763 | — | 1 | 6.53 |
| CHEMBL300389 | — | — | 1 | 6.52 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.49 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.46 |
| CHEMBL514499 | GW843682X | — | 1 | 6.36 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.17 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.14 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.10 |
| CHEMBL585951 | — | — | 1 | 6.09 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.03 |
| CHEMBL1256459 | TORIN1 | — | 1 | 5.88 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9066 | nM | 9.04 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1.983 | nM | 8.70 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.418 | nM | 8.47 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.534 | nM | 8.26 |
| CHEMBL188678 | — | IC50 | = | 21.43 | nM | 7.67 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 25.74 | nM | 7.59 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 28.46 | nM | 7.55 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 46.97 | nM | 7.33 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 55.04 | nM | 7.26 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 58.79 | nM | 7.23 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 102.8 | nM | 6.99 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 102.49 | nM | 6.99 |
| CHEMBL512504 | — | IC50 | = | 108.65 | nM | 6.96 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 123.86 | nM | 6.91 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 133.21 | nM | 6.88 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 157.32 | nM | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 236.24 | nM | 6.63 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 243.14 | nM | 6.61 |
| CHEMBL102714 | SB-216763 | IC50 | = | 293.92 | nM | 6.53 |
| CHEMBL300389 | — | IC50 | = | 305.11 | nM | 6.52 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 326.74 | nM | 6.49 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 342.65 | nM | 6.46 |
| CHEMBL514499 | GW843682X | IC50 | = | 442.07 | nM | 6.36 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 674.03 | nM | 6.17 |
| CHEMBL939 | GEFITINIB | IC50 | = | 722.4 | nM | 6.14 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 802.1 | nM | 6.10 |
| CHEMBL585951 | — | IC50 | = | 804.64 | nM | 6.09 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 940.55 | nM | 6.03 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 1329.28 | nM | 5.88 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1313.82 | nM | 5.88 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1485.36 | nM | 5.83 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1511.13 | nM | 5.82 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1520.54 | nM | 5.82 |
| CHEMBL1190711 | — | IC50 | = | 2611.04 | nM | 5.58 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 3022.07 | nM | 5.52 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 3805.23 | nM | 5.42 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3865.39 | nM | 5.41 |
| CHEMBL1673039 | — | IC50 | = | 4736.01 | nM | 5.33 |
| CHEMBL1242367 | — | IC50 | = | 5084.09 | nM | 5.29 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 5290.92 | nM | 5.28 |
| CHEMBL941 | IMATINIB | IC50 | = | 5572.62 | nM | 5.25 |
| CHEMBL3349342 | — | IC50 | = | 5647.82 | nM | 5.25 |
| CHEMBL477989 | SB590885 | IC50 | = | 6048.86 | nM | 5.22 |
| CHEMBL189584 | PD-173074 | IC50 | = | 5950.32 | nM | 5.22 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 6208.74 | nM | 5.21 |
| CHEMBL513909 | BI-2536 | IC50 | = | 6669.04 | nM | 5.18 |
| CHEMBL379975 | — | IC50 | = | 7532.69 | nM | 5.12 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 8380.02 | nM | 5.08 |
| CHEMBL259181 | — | IC50 | = | 8898.75 | nM | 5.05 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 8902.65 | nM | 5.05 |