Assay Detail
Functional
CHEMBL2363498
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SANGER: Inhibition of human NCI-H2009 cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2009 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.68 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.21 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.06 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.79 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.07 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.69 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.56 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.29 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.82 |
| CHEMBL217354 | — | — | 1 | 6.61 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.54 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.50 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.46 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.44 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.31 |
| CHEMBL585951 | — | — | 1 | 6.29 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.16 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.07 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.91 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.75 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.69 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.67 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.65 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.60 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.59 |
| CHEMBL2363137 | — | — | 1 | 5.57 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.48 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.44 |
| CHEMBL558642 | GSK-650394 | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.6187 | nM | 9.21 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.8623 | nM | 9.06 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.635 | nM | 8.79 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.458 | nM | 8.07 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 20.54 | nM | 7.69 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 51.76 | nM | 7.29 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 53.45 | nM | 7.27 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 68.13 | nM | 7.17 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 151.41 | nM | 6.82 |
| CHEMBL217354 | — | IC50 | = | 244.66 | nM | 6.61 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 288.57 | nM | 6.54 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 317.49 | nM | 6.50 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 347.39 | nM | 6.46 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 363.36 | nM | 6.44 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 486.89 | nM | 6.31 |
| CHEMBL585951 | — | IC50 | = | 507.68 | nM | 6.29 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 696.55 | nM | 6.16 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 853.11 | nM | 6.07 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1227.96 | nM | 5.91 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1797.21 | nM | 5.75 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2062.14 | nM | 5.69 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2148.93 | nM | 5.67 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2252.95 | nM | 5.65 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2529.34 | nM | 5.60 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2564.38 | nM | 5.59 |
| CHEMBL2363137 | — | IC50 | = | 2687.7 | nM | 5.57 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3290.1 | nM | 5.48 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 3612.16 | nM | 5.44 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3755.24 | nM | 5.42 |
| CHEMBL472940 | — | IC50 | = | 5043.54 | nM | 5.30 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 5014.24 | nM | 5.30 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 5305.38 | nM | 5.28 |
| CHEMBL258844 | — | IC50 | = | 7390.19 | nM | 5.13 |
| CHEMBL1190711 | — | IC50 | = | 9991.72 | nM | 5.00 |
| CHEMBL221137 | EMBELIN | IC50 | = | 11910.29 | nM | 4.92 |
| CHEMBL102714 | SB-216763 | IC50 | = | 13242.68 | nM | 4.88 |
| CHEMBL191384 | — | IC50 | = | 13065.38 | nM | 4.88 |
| CHEMBL105442 | CI-1040 | IC50 | = | 13591.91 | nM | 4.87 |
| CHEMBL512504 | — | IC50 | = | 14287.01 | nM | 4.84 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 15314.39 | nM | 4.82 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 15509.52 | nM | 4.81 |
| CHEMBL573107 | — | IC50 | = | 16926.58 | nM | 4.77 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 18781.47 | nM | 4.73 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 29143.07 | nM | 4.54 |
| CHEMBL591429 | PAC-1 | IC50 | = | 31537.24 | nM | 4.50 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 32498.14 | nM | 4.49 |
| CHEMBL259181 | — | IC50 | = | 32279.84 | nM | 4.49 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 33400.74 | nM | 4.48 |
| CHEMBL472004 | — | IC50 | = | 41486.62 | nM | 4.38 |