Assay Detail
Functional
CHEMBL2363501
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SANGER: Inhibition of human NCI-H2052 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2052 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.47 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.19 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.14 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.55 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.21 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.21 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.20 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.98 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.84 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.79 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.76 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.50 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.37 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.31 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.27 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.25 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.16 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.04 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.88 |
| CHEMBL217354 | — | — | 1 | 5.86 |
| CHEMBL585951 | — | — | 1 | 5.78 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 5.76 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.73 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.70 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.69 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.60 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.53 |
| CHEMBL2137530 | SERDEMETAN | 2.0 | 1 | 5.51 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.44 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.402 | nM | 8.19 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 7.268 | nM | 8.14 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 24.65 | nM | 7.61 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 28.34 | nM | 7.55 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 60.98 | nM | 7.21 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 61.13 | nM | 7.21 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 63.31 | nM | 7.20 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 104.07 | nM | 6.98 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 144.82 | nM | 6.84 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 160.47 | nM | 6.79 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 174.9 | nM | 6.76 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 314.84 | nM | 6.50 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 429.39 | nM | 6.37 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 487.99 | nM | 6.31 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 536.47 | nM | 6.27 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 567.41 | nM | 6.25 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 698.94 | nM | 6.16 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 915.25 | nM | 6.04 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1305.07 | nM | 5.88 |
| CHEMBL217354 | — | IC50 | = | 1392.93 | nM | 5.86 |
| CHEMBL585951 | — | IC50 | = | 1652.43 | nM | 5.78 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 1722.01 | nM | 5.76 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1864.1 | nM | 5.73 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1988.12 | nM | 5.70 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2041.59 | nM | 5.69 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 2509.68 | nM | 5.60 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2965.13 | nM | 5.53 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 3081.57 | nM | 5.51 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 3600.09 | nM | 5.44 |
| CHEMBL803 | CYTARABINE | IC50 | = | 4056.79 | nM | 5.39 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 5062.57 | nM | 5.30 |
| CHEMBL591429 | PAC-1 | IC50 | = | 7661.21 | nM | 5.12 |
| CHEMBL221137 | EMBELIN | IC50 | = | 8532.03 | nM | 5.07 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10188.22 | nM | 4.99 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 10510.51 | nM | 4.98 |
| CHEMBL1186585 | — | IC50 | = | 11462.88 | nM | 4.94 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 11450.19 | nM | 4.94 |
| CHEMBL573107 | — | IC50 | = | 13384.79 | nM | 4.87 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 13470.59 | nM | 4.87 |
| CHEMBL2363137 | — | IC50 | = | 18226.43 | nM | 4.74 |
| CHEMBL3349342 | — | IC50 | = | 19504.83 | nM | 4.71 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 21296.85 | nM | 4.67 |
| CHEMBL1190711 | — | IC50 | = | 21176.46 | nM | 4.67 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 21896.29 | nM | 4.66 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 27086.0 | nM | 4.57 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 27568.42 | nM | 4.56 |
| CHEMBL135561 | — | IC50 | = | 28400.85 | nM | 4.55 |
| CHEMBL191384 | — | IC50 | = | 29524.58 | nM | 4.53 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 40040.6 | nM | 4.40 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 42043.97 | nM | 4.38 |