Assay Detail
Functional
CHEMBL2363523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human NCI-H292 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H292 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.90 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.80 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 9.05 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.85 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.65 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.52 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.01 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.83 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.77 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.57 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.36 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.35 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.32 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.21 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.04 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.94 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.88 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.79 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.75 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.54 |
| CHEMBL217354 | — | — | 1 | 6.44 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.43 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.36 |
| CHEMBL379975 | — | — | 1 | 6.34 |
| CHEMBL585951 | — | — | 1 | 6.29 |
| CHEMBL3349342 | — | — | 1 | 6.19 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.11 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.09 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1585 | nM | 9.80 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 0.8859 | nM | 9.05 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.419 | nM | 8.85 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2.24 | nM | 8.65 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.03 | nM | 8.52 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.053 | nM | 8.30 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 9.837 | nM | 8.01 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 14.93 | nM | 7.83 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.09 | nM | 7.77 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 20.79 | nM | 7.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 43.76 | nM | 7.36 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 44.93 | nM | 7.35 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 47.39 | nM | 7.32 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 60.9 | nM | 7.21 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 91.42 | nM | 7.04 |
| CHEMBL803 | CYTARABINE | IC50 | = | 114.2 | nM | 6.94 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 131.1 | nM | 6.88 |
| CHEMBL939 | GEFITINIB | IC50 | = | 162.66 | nM | 6.79 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 176.01 | nM | 6.75 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 291.64 | nM | 6.54 |
| CHEMBL217354 | — | IC50 | = | 360.23 | nM | 6.44 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 369.62 | nM | 6.43 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 441.08 | nM | 6.36 |
| CHEMBL379975 | — | IC50 | = | 453.64 | nM | 6.34 |
| CHEMBL585951 | — | IC50 | = | 507.54 | nM | 6.29 |
| CHEMBL3349342 | — | IC50 | = | 639.69 | nM | 6.19 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 773.93 | nM | 6.11 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 803.16 | nM | 6.09 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 853.29 | nM | 6.07 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 897.77 | nM | 6.05 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 884.41 | nM | 6.05 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 974.32 | nM | 6.01 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1119.9 | nM | 5.95 |
| CHEMBL573107 | — | IC50 | = | 1460.69 | nM | 5.83 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1562.67 | nM | 5.81 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1663.83 | nM | 5.78 |
| CHEMBL202721 | — | IC50 | = | 1695.55 | nM | 5.77 |
| CHEMBL188678 | — | IC50 | = | 1740.13 | nM | 5.76 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1866.99 | nM | 5.73 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2239.51 | nM | 5.65 |
| CHEMBL577784 | BX-795 | IC50 | = | 2577.22 | nM | 5.59 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2865.96 | nM | 5.54 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 2850.53 | nM | 5.54 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3120.28 | nM | 5.51 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3649.28 | nM | 5.44 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4094.29 | nM | 5.39 |
| CHEMBL477989 | SB590885 | IC50 | = | 4375.94 | nM | 5.36 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 4381.46 | nM | 5.36 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4709.5 | nM | 5.33 |