Assay Detail
Functional
CHEMBL2363530
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SANGER: Inhibition of human NCI-H460 cell growth in a cell viability assay.
95
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 95 | 5.72 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.48 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.19 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.16 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.08 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.90 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.87 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.87 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.71 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.62 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.33 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.09 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.00 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.84 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.63 |
| CHEMBL217354 | — | — | 1 | 6.51 |
| CHEMBL585951 | — | — | 1 | 6.47 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.30 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.93 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.89 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.82 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.69 |
| CHEMBL577784 | BX-795 | — | 1 | 5.61 |
| CHEMBL1190711 | — | — | 1 | 5.61 |
| CHEMBL3349342 | — | — | 1 | 5.60 |
| CHEMBL259181 | — | — | 1 | 5.56 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.55 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 5.53 |
| CHEMBL202721 | — | — | 1 | 5.51 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.3333 | nM | 9.48 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 6.452 | nM | 8.19 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.983 | nM | 8.16 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.369 | nM | 8.08 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 13.36 | nM | 7.87 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 13.54 | nM | 7.87 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 19.74 | nM | 7.71 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 24.12 | nM | 7.62 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 46.39 | nM | 7.33 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 81.23 | nM | 7.09 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 90.12 | nM | 7.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 100.9 | nM | 7.00 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 144.66 | nM | 6.84 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 235.71 | nM | 6.63 |
| CHEMBL217354 | — | IC50 | = | 305.74 | nM | 6.51 |
| CHEMBL585951 | — | IC50 | = | 337.26 | nM | 6.47 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 505.97 | nM | 6.30 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1169.86 | nM | 5.93 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1277.69 | nM | 5.89 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1529.61 | nM | 5.82 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 2048.39 | nM | 5.69 |
| CHEMBL577784 | BX-795 | IC50 | = | 2439.55 | nM | 5.61 |
| CHEMBL1190711 | — | IC50 | = | 2464.44 | nM | 5.61 |
| CHEMBL3349342 | — | IC50 | = | 2521.3 | nM | 5.60 |
| CHEMBL259181 | — | IC50 | = | 2733.89 | nM | 5.56 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 2802.74 | nM | 5.55 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2956.62 | nM | 5.53 |
| CHEMBL202721 | — | IC50 | = | 3069.92 | nM | 5.51 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3263.06 | nM | 5.49 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3404.1 | nM | 5.47 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 3667.3 | nM | 5.44 |
| CHEMBL2363137 | — | IC50 | = | 3655.07 | nM | 5.44 |
| CHEMBL399530 | — | IC50 | = | 4108.99 | nM | 5.39 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 4264.43 | nM | 5.37 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4577.6 | nM | 5.34 |
| CHEMBL258844 | — | IC50 | = | 4629.93 | nM | 5.33 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 4755.06 | nM | 5.32 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 4911.27 | nM | 5.31 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4927.62 | nM | 5.31 |
| CHEMBL221137 | EMBELIN | IC50 | = | 6088.05 | nM | 5.22 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8006.94 | nM | 5.10 |
| CHEMBL803 | CYTARABINE | IC50 | = | 9640.1 | nM | 5.02 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 10280.63 | nM | 4.99 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 11256.53 | nM | 4.95 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 11962.93 | nM | 4.92 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 16732.63 | nM | 4.78 |
| CHEMBL135561 | — | IC50 | = | 17086.97 | nM | 4.77 |
| CHEMBL573107 | — | IC50 | = | 18846.65 | nM | 4.72 |
| CHEMBL191384 | — | IC50 | = | 19107.85 | nM | 4.72 |