Assay Detail
Functional
CHEMBL2363545
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SANGER: Inhibition of human NCI-H727 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H727 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.45 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.75 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.60 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.08 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.64 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.61 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.52 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.09 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.75 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.70 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.67 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.65 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.38 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.33 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.20 |
| CHEMBL585951 | — | — | 1 | 6.19 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.16 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.11 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.06 |
| CHEMBL191384 | — | — | 1 | 6.05 |
| CHEMBL217354 | — | — | 1 | 6.03 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.00 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.96 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.95 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.78 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.71 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.70 |
| CHEMBL2363137 | — | — | 1 | 5.69 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.796 | nM | 8.75 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.506 | nM | 8.60 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.364 | nM | 8.08 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 19.02 | nM | 7.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.79 | nM | 7.64 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 24.74 | nM | 7.61 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 30.11 | nM | 7.52 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 80.53 | nM | 7.09 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 175.7 | nM | 6.75 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 197.94 | nM | 6.70 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 211.8 | nM | 6.67 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 224.54 | nM | 6.65 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 412.11 | nM | 6.38 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 471.86 | nM | 6.33 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 638.3 | nM | 6.20 |
| CHEMBL585951 | — | IC50 | = | 646.94 | nM | 6.19 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 698.12 | nM | 6.16 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 768.26 | nM | 6.11 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 874.26 | nM | 6.06 |
| CHEMBL191384 | — | IC50 | = | 893.27 | nM | 6.05 |
| CHEMBL217354 | — | IC50 | = | 940.97 | nM | 6.03 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1009.34 | nM | 6.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1101.54 | nM | 5.96 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1127.99 | nM | 5.95 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1666.82 | nM | 5.78 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1949.08 | nM | 5.71 |
| CHEMBL591429 | PAC-1 | IC50 | = | 2003.76 | nM | 5.70 |
| CHEMBL2363137 | — | IC50 | = | 2033.74 | nM | 5.69 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2917.96 | nM | 5.54 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3265.8 | nM | 5.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3385.84 | nM | 5.47 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 5409.01 | nM | 5.27 |
| CHEMBL1190711 | — | IC50 | = | 6145.71 | nM | 5.21 |
| CHEMBL221137 | EMBELIN | IC50 | = | 7881.1 | nM | 5.10 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 8104.2 | nM | 5.09 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 10310.21 | nM | 4.99 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 10449.48 | nM | 4.98 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 11139.18 | nM | 4.95 |
| CHEMBL259181 | — | IC50 | = | 12989.87 | nM | 4.89 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 15422.05 | nM | 4.81 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 19329.53 | nM | 4.71 |
| CHEMBL472940 | — | IC50 | = | 19749.71 | nM | 4.70 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 20270.37 | nM | 4.69 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 20216.88 | nM | 4.69 |
| CHEMBL477989 | SB590885 | IC50 | = | 20740.33 | nM | 4.68 |
| CHEMBL573107 | — | IC50 | = | 21349.28 | nM | 4.67 |
| CHEMBL188678 | — | IC50 | = | 22734.96 | nM | 4.64 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 22883.59 | nM | 4.64 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 26051.28 | nM | 4.58 |