Assay Detail
Functional
CHEMBL2363558
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SANGER: Inhibition of human NKM-1 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NKM-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.97 | 9.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 9.38 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.36 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.89 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.70 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.21 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.18 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.12 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.11 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.01 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.53 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.50 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 7.40 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.33 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.26 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.13 |
| CHEMBL300389 | — | — | 1 | 7.10 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.01 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.97 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.96 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.96 |
| CHEMBL514499 | GW843682X | — | 1 | 6.86 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.83 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.70 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2041933 | AZD-7762 | IC50 | = | 0.415 | nM | 9.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.441 | nM | 9.36 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.273 | nM | 8.89 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.999 | nM | 8.70 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.103 | nM | 8.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.972 | nM | 8.30 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 5.472 | nM | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.119 | nM | 8.21 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 6.548 | nM | 8.18 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 7.647 | nM | 8.12 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7.702 | nM | 8.11 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 7.831 | nM | 8.11 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 9.719 | nM | 8.01 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 16.99 | nM | 7.77 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 29.47 | nM | 7.53 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 31.69 | nM | 7.50 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 39.42 | nM | 7.40 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 54.81 | nM | 7.26 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 74.16 | nM | 7.13 |
| CHEMBL300389 | — | IC50 | = | 79.11 | nM | 7.10 |
| CHEMBL535 | SUNITINIB | IC50 | = | 98.52 | nM | 7.01 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 101.2 | nM | 7.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 106.66 | nM | 6.97 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 109.12 | nM | 6.96 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL514499 | GW843682X | IC50 | = | 138.09 | nM | 6.86 |
| CHEMBL513909 | BI-2536 | IC50 | = | 149.06 | nM | 6.83 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 199.89 | nM | 6.70 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 200.29 | nM | 6.70 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 197.98 | nM | 6.70 |
| CHEMBL577784 | BX-795 | IC50 | = | 361.94 | nM | 6.44 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 385.8 | nM | 6.41 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 411.89 | nM | 6.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 425.16 | nM | 6.37 |
| CHEMBL585951 | — | IC50 | = | 425.48 | nM | 6.37 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 509.25 | nM | 6.29 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 544.27 | nM | 6.26 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 593.09 | nM | 6.23 |
| CHEMBL2144069 | — | IC50 | = | 735.37 | nM | 6.13 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 774.18 | nM | 6.11 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 862.53 | nM | 6.06 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 901.5 | nM | 6.04 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 960.24 | nM | 6.02 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 986.63 | nM | 6.01 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1027.75 | nM | 5.99 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1049.31 | nM | 5.98 |
| CHEMBL1190711 | — | IC50 | = | 1057.0 | nM | 5.98 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1064.03 | nM | 5.97 |
| CHEMBL202721 | — | IC50 | = | 1167.98 | nM | 5.93 |