Assay Detail
Functional
CHEMBL2363560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human NOMO-1 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NOMO-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.71 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.81 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.68 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.36 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.29 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.11 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.07 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.79 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.72 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.54 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 7.50 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.34 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.21 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.14 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.03 |
| CHEMBL3349342 | — | — | 1 | 6.86 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.83 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.82 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.78 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.65 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.59 |
| CHEMBL512504 | — | — | 1 | 6.58 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.52 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.40 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.36 |
| CHEMBL585951 | — | — | 1 | 6.33 |
| CHEMBL514499 | GW843682X | — | 1 | 6.26 |
| CHEMBL379300 | A-443654 | — | 1 | 6.25 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.25 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.09 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.557 | nM | 8.81 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2.072 | nM | 8.68 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.328 | nM | 8.36 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.859 | nM | 8.11 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 8.553 | nM | 8.07 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 16.25 | nM | 7.79 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 19.02 | nM | 7.72 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 28.68 | nM | 7.54 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 31.97 | nM | 7.50 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 45.87 | nM | 7.34 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 61.15 | nM | 7.21 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 71.72 | nM | 7.14 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 92.75 | nM | 7.03 |
| CHEMBL3349342 | — | IC50 | = | 137.29 | nM | 6.86 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 149.5 | nM | 6.83 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 151.41 | nM | 6.82 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 167.56 | nM | 6.78 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 224.43 | nM | 6.65 |
| CHEMBL105442 | CI-1040 | IC50 | = | 257.42 | nM | 6.59 |
| CHEMBL512504 | — | IC50 | = | 263.22 | nM | 6.58 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 300.21 | nM | 6.52 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 399.71 | nM | 6.40 |
| CHEMBL513909 | BI-2536 | IC50 | = | 438.6 | nM | 6.36 |
| CHEMBL585951 | — | IC50 | = | 462.61 | nM | 6.33 |
| CHEMBL514499 | GW843682X | IC50 | = | 551.29 | nM | 6.26 |
| CHEMBL379300 | A-443654 | IC50 | = | 560.7 | nM | 6.25 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 563.72 | nM | 6.25 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 810.84 | nM | 6.09 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 965.64 | nM | 6.01 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1155.91 | nM | 5.94 |
| CHEMBL2144069 | — | IC50 | = | 1206.38 | nM | 5.92 |
| CHEMBL202721 | — | IC50 | = | 1367.25 | nM | 5.86 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1569.82 | nM | 5.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2193.17 | nM | 5.66 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2176.83 | nM | 5.66 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2187.98 | nM | 5.66 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2168.52 | nM | 5.66 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2332.32 | nM | 5.63 |
| CHEMBL300389 | — | IC50 | = | 2649.84 | nM | 5.58 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2714.42 | nM | 5.57 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2905.68 | nM | 5.54 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 3022.74 | nM | 5.52 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3324.31 | nM | 5.48 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3492.04 | nM | 5.46 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 4201.51 | nM | 5.38 |
| CHEMBL379975 | — | IC50 | = | 4298.18 | nM | 5.37 |
| CHEMBL535 | SUNITINIB | IC50 | = | 4336.99 | nM | 5.36 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 4321.31 | nM | 5.36 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4489.05 | nM | 5.35 |