Assay Detail
Functional
CHEMBL2363561
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SANGER: Inhibition of human NOS-1 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NOS-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.87 | 10.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 10.44 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.08 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 9.06 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.68 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.62 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.57 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.21 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.19 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.84 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.82 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.80 |
| CHEMBL514499 | GW843682X | — | 1 | 7.78 |
| CHEMBL300389 | — | — | 1 | 7.71 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.52 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 7.51 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.49 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.39 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.19 |
| CHEMBL401930 | — | — | 1 | 7.13 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.10 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.04 |
| CHEMBL2144069 | — | — | 1 | 7.03 |
| CHEMBL379300 | A-443654 | — | 1 | 7.03 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.99 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.83 |
| CHEMBL197603 | — | — | 1 | 6.71 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.71 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 0.03664 | nM | 10.44 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.08247 | nM | 10.08 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 0.8712 | nM | 9.06 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.112 | nM | 8.68 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 2.415 | nM | 8.62 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.716 | nM | 8.57 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 6.129 | nM | 8.21 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.496 | nM | 8.19 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL535 | SUNITINIB | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 15.93 | nM | 7.80 |
| CHEMBL514499 | GW843682X | IC50 | = | 16.57 | nM | 7.78 |
| CHEMBL300389 | — | IC50 | = | 19.58 | nM | 7.71 |
| CHEMBL513909 | BI-2536 | IC50 | = | 20.93 | nM | 7.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 30.12 | nM | 7.52 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 30.84 | nM | 7.51 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 32.44 | nM | 7.49 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 40.88 | nM | 7.39 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 41.33 | nM | 7.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 64.11 | nM | 7.19 |
| CHEMBL401930 | — | IC50 | = | 74.41 | nM | 7.13 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 79.14 | nM | 7.10 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 91.86 | nM | 7.04 |
| CHEMBL2144069 | — | IC50 | = | 92.65 | nM | 7.03 |
| CHEMBL379300 | A-443654 | IC50 | = | 93.76 | nM | 7.03 |
| CHEMBL509032 | TAE-684 | IC50 | = | 102.94 | nM | 6.99 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 149.67 | nM | 6.83 |
| CHEMBL197603 | — | IC50 | = | 196.21 | nM | 6.71 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 196.19 | nM | 6.71 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 211.82 | nM | 6.67 |
| CHEMBL217354 | — | IC50 | = | 235.16 | nM | 6.63 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 243.67 | nM | 6.61 |
| CHEMBL585951 | — | IC50 | = | 306.7 | nM | 6.51 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 315.01 | nM | 6.50 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 410.74 | nM | 6.39 |
| CHEMBL1190711 | — | IC50 | = | 481.3 | nM | 6.32 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 522.67 | nM | 6.28 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 563.6 | nM | 6.25 |
| CHEMBL483847 | — | IC50 | = | 570.75 | nM | 6.24 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 605.29 | nM | 6.22 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 637.23 | nM | 6.20 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 659.87 | nM | 6.18 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 727.04 | nM | 6.14 |
| CHEMBL213100 | — | IC50 | = | 950.45 | nM | 6.02 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 948.69 | nM | 6.02 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 970.4 | nM | 6.01 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 974.89 | nM | 6.01 |
| CHEMBL209148 | — | IC50 | = | 1296.47 | nM | 5.89 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1305.44 | nM | 5.88 |
| CHEMBL258844 | — | IC50 | = | 1369.53 | nM | 5.86 |