Assay Detail
Functional
CHEMBL2363568
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SANGER: Inhibition of human OCI-AML2 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-AML2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.66 | 9.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.83 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.05 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.72 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.51 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.09 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.07 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.99 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.89 |
| CHEMBL2144069 | — | — | 1 | 7.77 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.54 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.53 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.35 |
| CHEMBL514499 | GW843682X | — | 1 | 7.30 |
| CHEMBL512504 | — | — | 1 | 7.24 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.24 |
| CHEMBL300389 | — | — | 1 | 7.20 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.08 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.87 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.86 |
| CHEMBL379300 | A-443654 | — | 1 | 6.68 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.62 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.58 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.53 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.49 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.32 |
| CHEMBL585951 | — | — | 1 | 6.30 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.29 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.26 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.25 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.1466 | nM | 9.83 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.8868 | nM | 9.05 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1.886 | nM | 8.72 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.066 | nM | 8.51 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.045 | nM | 8.09 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 8.521 | nM | 8.07 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 10.25 | nM | 7.99 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.81 | nM | 7.89 |
| CHEMBL2144069 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 28.71 | nM | 7.54 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 29.69 | nM | 7.53 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 45.05 | nM | 7.35 |
| CHEMBL514499 | GW843682X | IC50 | = | 49.86 | nM | 7.30 |
| CHEMBL512504 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 57.77 | nM | 7.24 |
| CHEMBL300389 | — | IC50 | = | 62.58 | nM | 7.20 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 82.61 | nM | 7.08 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 135.58 | nM | 6.87 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 138.49 | nM | 6.86 |
| CHEMBL379300 | A-443654 | IC50 | = | 210.37 | nM | 6.68 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 241.6 | nM | 6.62 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 265.63 | nM | 6.58 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 298.37 | nM | 6.53 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 322.98 | nM | 6.49 |
| CHEMBL509032 | TAE-684 | IC50 | = | 483.28 | nM | 6.32 |
| CHEMBL585951 | — | IC50 | = | 498.49 | nM | 6.30 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 514.04 | nM | 6.29 |
| CHEMBL803 | CYTARABINE | IC50 | = | 545.02 | nM | 6.26 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 559.35 | nM | 6.25 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 644.03 | nM | 6.19 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 653.97 | nM | 6.18 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1069.27 | nM | 5.97 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1266.66 | nM | 5.90 |
| CHEMBL401930 | — | IC50 | = | 1313.4 | nM | 5.88 |
| CHEMBL535 | SUNITINIB | IC50 | = | 1368.51 | nM | 5.86 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2032.09 | nM | 5.69 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2074.76 | nM | 5.68 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2255.37 | nM | 5.65 |
| CHEMBL2363137 | — | IC50 | = | 2517.3 | nM | 5.60 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 3312.72 | nM | 5.48 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 3626.71 | nM | 5.44 |
| CHEMBL1673039 | — | IC50 | = | 3598.01 | nM | 5.44 |
| CHEMBL202721 | — | IC50 | = | 3677.62 | nM | 5.43 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4194.89 | nM | 5.38 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 4215.39 | nM | 5.38 |
| CHEMBL1190711 | — | IC50 | = | 4484.97 | nM | 5.35 |
| CHEMBL513909 | BI-2536 | IC50 | = | 4552.3 | nM | 5.34 |
| CHEMBL191384 | — | IC50 | = | 4654.47 | nM | 5.33 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4652.38 | nM | 5.33 |
| CHEMBL197603 | — | IC50 | = | 5102.21 | nM | 5.29 |