Assay Detail
Functional
CHEMBL2363598
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SANGER: Inhibition of human RERF-LC-MS cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RERF-LC-MS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.56 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.95 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.86 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.07 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.82 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.64 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.61 |
| CHEMBL217354 | — | — | 1 | 7.45 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.91 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.87 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.37 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.34 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.26 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.17 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.13 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.09 |
| CHEMBL585951 | — | — | 1 | 6.06 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.99 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.97 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.95 |
| CHEMBL3349342 | — | — | 1 | 5.88 |
| CHEMBL2363137 | — | — | 1 | 5.83 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.75 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.60 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.50 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.40 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.40 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.368 | nM | 8.86 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 8.579 | nM | 8.07 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 10.18 | nM | 7.99 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 15.15 | nM | 7.82 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 22.87 | nM | 7.64 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL217354 | — | IC50 | = | 35.19 | nM | 7.45 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 124.31 | nM | 6.91 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 134.3 | nM | 6.87 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 176.69 | nM | 6.75 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 425.05 | nM | 6.37 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 454.32 | nM | 6.34 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 549.9 | nM | 6.26 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 676.71 | nM | 6.17 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 746.13 | nM | 6.13 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 812.46 | nM | 6.09 |
| CHEMBL585951 | — | IC50 | = | 873.94 | nM | 6.06 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1031.57 | nM | 5.99 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1063.49 | nM | 5.97 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1110.7 | nM | 5.95 |
| CHEMBL3349342 | — | IC50 | = | 1327.23 | nM | 5.88 |
| CHEMBL2363137 | — | IC50 | = | 1492.44 | nM | 5.83 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1764.45 | nM | 5.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2494.13 | nM | 5.60 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3175.49 | nM | 5.50 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 3983.53 | nM | 5.40 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 3965.25 | nM | 5.40 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 4189.97 | nM | 5.38 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4343.69 | nM | 5.36 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5069.03 | nM | 5.29 |
| CHEMBL577784 | BX-795 | IC50 | = | 5347.99 | nM | 5.27 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5688.03 | nM | 5.25 |
| CHEMBL399530 | — | IC50 | = | 6592.74 | nM | 5.18 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 8348.56 | nM | 5.08 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8485.95 | nM | 5.07 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 8822.51 | nM | 5.05 |
| CHEMBL135561 | — | IC50 | = | 10980.75 | nM | 4.96 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 17550.84 | nM | 4.76 |
| CHEMBL573107 | — | IC50 | = | 17912.86 | nM | 4.75 |
| CHEMBL379975 | — | IC50 | = | 19289.41 | nM | 4.71 |
| CHEMBL176544 | — | IC50 | = | 24562.87 | nM | 4.61 |
| CHEMBL258844 | — | IC50 | = | 26134.7 | nM | 4.58 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 26877.51 | nM | 4.57 |
| CHEMBL221137 | EMBELIN | IC50 | = | 30604.68 | nM | 4.51 |
| CHEMBL2134202 | — | IC50 | = | 32674.73 | nM | 4.49 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 32823.08 | nM | 4.48 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 34031.51 | nM | 4.47 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 38272.48 | nM | 4.42 |