Assay Detail
Functional
CHEMBL2363622
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SANGER: Inhibition of human SBC-5 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SBC-5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.72 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.04 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.73 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.68 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.59 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.13 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.09 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.90 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.68 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.67 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.49 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.16 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.08 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.04 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.99 |
| CHEMBL217354 | — | — | 1 | 6.83 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.70 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.67 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.67 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.59 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.52 |
| CHEMBL585951 | — | — | 1 | 6.40 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.33 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.29 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.21 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.89 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.81 |
| CHEMBL2363137 | — | — | 1 | 5.79 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.69 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.55 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.9115 | nM | 9.04 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.874 | nM | 8.73 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2.082 | nM | 8.68 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2.589 | nM | 8.59 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 7.471 | nM | 8.13 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.083 | nM | 8.09 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 12.57 | nM | 7.90 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.74 | nM | 7.68 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 21.62 | nM | 7.67 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 32.15 | nM | 7.49 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 69.36 | nM | 7.16 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 83.52 | nM | 7.08 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 91.93 | nM | 7.04 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 103.06 | nM | 6.99 |
| CHEMBL217354 | — | IC50 | = | 147.12 | nM | 6.83 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 201.18 | nM | 6.70 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 212.15 | nM | 6.67 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 215.46 | nM | 6.67 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 254.06 | nM | 6.59 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 302.62 | nM | 6.52 |
| CHEMBL585951 | — | IC50 | = | 397.61 | nM | 6.40 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 470.41 | nM | 6.33 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 513.44 | nM | 6.29 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 623.55 | nM | 6.21 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1273.89 | nM | 5.89 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1545.93 | nM | 5.81 |
| CHEMBL2363137 | — | IC50 | = | 1612.01 | nM | 5.79 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2061.47 | nM | 5.69 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2810.94 | nM | 5.55 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3678.82 | nM | 5.43 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 6972.97 | nM | 5.16 |
| CHEMBL191384 | — | IC50 | = | 6893.55 | nM | 5.16 |
| CHEMBL577784 | BX-795 | IC50 | = | 8861.36 | nM | 5.05 |
| CHEMBL202721 | — | IC50 | = | 10554.1 | nM | 4.98 |
| CHEMBL399530 | — | IC50 | = | 10737.46 | nM | 4.97 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 10904.45 | nM | 4.96 |
| CHEMBL105442 | CI-1040 | IC50 | = | 11146.68 | nM | 4.95 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11407.09 | nM | 4.94 |
| CHEMBL1190711 | — | IC50 | = | 13305.76 | nM | 4.88 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 14136.2 | nM | 4.85 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 14950.0 | nM | 4.83 |
| CHEMBL259181 | — | IC50 | = | 16501.76 | nM | 4.78 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 17147.89 | nM | 4.77 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 19029.97 | nM | 4.72 |
| CHEMBL803 | CYTARABINE | IC50 | = | 19506.45 | nM | 4.71 |
| CHEMBL258844 | — | IC50 | = | 20832.47 | nM | 4.68 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 25114.74 | nM | 4.60 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 25032.8 | nM | 4.60 |
| CHEMBL1186585 | — | IC50 | = | 27098.25 | nM | 4.57 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 32851.09 | nM | 4.48 |