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Assay Detail

CHEMBL2363636

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Functional
SANGER: Inhibition of human SIG-M5 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SIG-M5
Confidence 1 — Organism
Curated By Autocuration

Target

SIG-M5 (CHEMBL2366251) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 6.35 10.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.98
CHEMBL94657 PATUPILONE 3.0 1 9.77
CHEMBL96926 THAPSIGARGIN — 1 9.39
CHEMBL1023 BEXAROTENE 4.0 1 9.18
CHEMBL449158 BRYOSTATIN 1 2.0 1 8.81
CHEMBL553025 VINORELBINE 4.0 1 8.61
CHEMBL428647 PACLITAXEL 4.0 1 8.48
CHEMBL105 MITOMYCIN 4.0 1 8.45
CHEMBL252164 LUMINESPIB 2.0 1 8.31
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 8.15
CHEMBL512504 — — 1 8.11
CHEMBL2144069 — — 1 8.02
CHEMBL289228 TIPIFARNIB 3.0 1 7.84
CHEMBL413 SIROLIMUS 4.0 1 7.76
CHEMBL514499 GW843682X — 1 7.68
CHEMBL53463 DOXORUBICIN 4.0 1 7.59
CHEMBL300389 — — 1 7.53
CHEMBL575448 BMS-754807 2.0 1 7.32
CHEMBL1256459 TORIN1 — 1 7.05
CHEMBL325041 BORTEZOMIB 3.0 1 6.98
CHEMBL585951 — — 1 6.91
CHEMBL44657 ETOPOSIDE 4.0 1 6.88
CHEMBL379300 A-443654 — 1 6.88
CHEMBL1171837 PONATINIB 4.0 1 6.87
CHEMBL572878 TOZASERTIB 2.0 1 6.78
CHEMBL9470 SHIKONIN — 1 6.77
CHEMBL513909 BI-2536 2.0 1 6.64
CHEMBL509032 TAE-684 — 1 6.54
CHEMBL401930 — — 1 6.49
CHEMBL608533 MIDOSTAURIN 4.0 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.01042 nM 10.98
CHEMBL94657 PATUPILONE IC50 = 0.1687 nM 9.77
CHEMBL96926 THAPSIGARGIN IC50 = 0.4094 nM 9.39
CHEMBL1023 BEXAROTENE IC50 = 0.6582 nM 9.18
CHEMBL449158 BRYOSTATIN 1 IC50 = 1.562 nM 8.81
CHEMBL553025 VINORELBINE IC50 = 2.476 nM 8.61
CHEMBL428647 PACLITAXEL IC50 = 3.272 nM 8.48
CHEMBL105 MITOMYCIN IC50 = 3.524 nM 8.45
CHEMBL252164 LUMINESPIB IC50 = 4.893 nM 8.31
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 7.104 nM 8.15
CHEMBL512504 — IC50 = 7.856 nM 8.11
CHEMBL2144069 — IC50 = 9.455 nM 8.02
CHEMBL289228 TIPIFARNIB IC50 = 14.57 nM 7.84
CHEMBL413 SIROLIMUS IC50 = 17.25 nM 7.76
CHEMBL514499 GW843682X IC50 = 21.04 nM 7.68
CHEMBL53463 DOXORUBICIN IC50 = 25.69 nM 7.59
CHEMBL300389 — IC50 = 29.86 nM 7.53
CHEMBL575448 BMS-754807 IC50 = 48.19 nM 7.32
CHEMBL1256459 TORIN1 IC50 = 89.04 nM 7.05
CHEMBL325041 BORTEZOMIB IC50 = 105.06 nM 6.98
CHEMBL585951 — IC50 = 124.13 nM 6.91
CHEMBL44657 ETOPOSIDE IC50 = 130.82 nM 6.88
CHEMBL379300 A-443654 IC50 = 130.47 nM 6.88
CHEMBL1171837 PONATINIB IC50 = 133.7 nM 6.87
CHEMBL572878 TOZASERTIB IC50 = 167.07 nM 6.78
CHEMBL9470 SHIKONIN IC50 = 169.86 nM 6.77
CHEMBL513909 BI-2536 IC50 = 227.27 nM 6.64
CHEMBL509032 TAE-684 IC50 = 291.59 nM 6.54
CHEMBL401930 — IC50 = 322.79 nM 6.49
CHEMBL608533 MIDOSTAURIN IC50 = 482.99 nM 6.32
CHEMBL1091644 LINSITINIB IC50 = 535.57 nM 6.27
CHEMBL27759 ENTINOSTAT IC50 = 578.48 nM 6.24
CHEMBL6067492 BLEOMYCIN IC50 = 586.05 nM 6.23
CHEMBL259181 — IC50 = 654.33 nM 6.18
CHEMBL1190711 — IC50 = 848.16 nM 6.07
CHEMBL221137 EMBELIN IC50 = 1310.62 nM 5.88
CHEMBL535 SUNITINIB IC50 = 1370.09 nM 5.86
CHEMBL1084546 PF-00562271 IC50 = 1483.87 nM 5.83
CHEMBL472940 — IC50 = 2102.19 nM 5.68
CHEMBL1336 SORAFENIB IC50 = 2422.42 nM 5.62
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 2767.43 nM 5.56
CHEMBL2363137 — IC50 = 3363.39 nM 5.47
CHEMBL558642 GSK-650394 IC50 = 4878.38 nM 5.31
CHEMBL1673039 — IC50 = 5355.45 nM 5.27
CHEMBL2165191 AZD-6482 IC50 = 5422.9 nM 5.27
CHEMBL197603 — IC50 = 5844.62 nM 5.23
CHEMBL591429 PAC-1 IC50 = 7684.76 nM 5.11
CHEMBL36 PYRIMETHAMINE IC50 = 7984.28 nM 5.10
CHEMBL209148 — IC50 = 8065.04 nM 5.09
CHEMBL5416410 DASATINIB IC50 = 9024.93 nM 5.04