Assay Detail
Functional
CHEMBL2363649
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SANGER: Inhibition of human SK-MEL-30 cell growth in a cell viability assay.
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-30 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 5.56 | 9.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 9.45 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.26 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.87 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.49 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.13 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.91 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.45 |
| CHEMBL217354 | — | — | 1 | 7.42 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.36 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.05 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.71 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.42 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.40 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.38 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.32 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.29 |
| CHEMBL585951 | — | — | 1 | 6.23 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.16 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.11 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.04 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.92 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 5.88 |
| CHEMBL477989 | SB590885 | — | 1 | 5.81 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.67 |
| CHEMBL379975 | — | — | 1 | 5.67 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.64 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.62 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.60 |
| CHEMBL188678 | — | — | 1 | 5.46 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 0.3552 | nM | 9.45 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.5545 | nM | 9.26 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.343 | nM | 8.87 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 3.244 | nM | 8.49 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 7.323 | nM | 8.13 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.41 | nM | 7.91 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35.61 | nM | 7.45 |
| CHEMBL217354 | — | IC50 | = | 37.97 | nM | 7.42 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 43.62 | nM | 7.36 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 89.47 | nM | 7.05 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 196.2 | nM | 6.71 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 376.88 | nM | 6.42 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 399.13 | nM | 6.40 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 415.46 | nM | 6.38 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 474.31 | nM | 6.32 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 511.72 | nM | 6.29 |
| CHEMBL585951 | — | IC50 | = | 588.48 | nM | 6.23 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 694.8 | nM | 6.16 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 781.71 | nM | 6.11 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 911.85 | nM | 6.04 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1196.99 | nM | 5.92 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 1333.86 | nM | 5.88 |
| CHEMBL477989 | SB590885 | IC50 | = | 1551.38 | nM | 5.81 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2123.09 | nM | 5.67 |
| CHEMBL379975 | — | IC50 | = | 2118.28 | nM | 5.67 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 2281.97 | nM | 5.64 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2384.57 | nM | 5.62 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2488.3 | nM | 5.60 |
| CHEMBL188678 | — | IC50 | = | 3425.98 | nM | 5.46 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3659.21 | nM | 5.44 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3743.33 | nM | 5.43 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3851.21 | nM | 5.41 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 4419.13 | nM | 5.36 |
| CHEMBL2363137 | — | IC50 | = | 5760.26 | nM | 5.24 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5745.43 | nM | 5.24 |
| CHEMBL202721 | — | IC50 | = | 6673.99 | nM | 5.18 |
| CHEMBL135561 | — | IC50 | = | 6819.38 | nM | 5.17 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 6963.15 | nM | 5.16 |
| CHEMBL105442 | CI-1040 | IC50 | = | 7250.83 | nM | 5.14 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7972.15 | nM | 5.10 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 8244.05 | nM | 5.08 |
| CHEMBL259181 | — | IC50 | = | 8891.42 | nM | 5.05 |
| CHEMBL591429 | PAC-1 | IC50 | = | 9616.71 | nM | 5.02 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 9944.76 | nM | 5.00 |
| CHEMBL189584 | PD-173074 | IC50 | = | 10890.1 | nM | 4.96 |
| CHEMBL3349342 | — | IC50 | = | 11182.79 | nM | 4.95 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 11407.94 | nM | 4.94 |
| CHEMBL577784 | BX-795 | IC50 | = | 11730.7 | nM | 4.93 |
| CHEMBL221137 | EMBELIN | IC50 | = | 12795.2 | nM | 4.89 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 14064.53 | nM | 4.85 |