Assay Detail
Functional
CHEMBL2363695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human SW954 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW 954 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.81 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.36 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.09 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.93 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.54 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.22 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 8.02 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.02 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.97 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.85 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.81 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.77 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.77 |
| CHEMBL514499 | GW843682X | — | 1 | 7.74 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.69 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.63 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.53 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.42 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.35 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.97 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.91 |
| CHEMBL300389 | — | — | 1 | 6.77 |
| CHEMBL379300 | A-443654 | — | 1 | 6.75 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.67 |
| CHEMBL379975 | — | — | 1 | 6.67 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.63 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.54 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.53 |
| CHEMBL213100 | — | — | 1 | 6.43 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.40 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.4357 | nM | 9.36 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.8228 | nM | 9.09 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.187 | nM | 8.93 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.898 | nM | 8.54 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.983 | nM | 8.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 9.662 | nM | 8.02 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 9.572 | nM | 8.02 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.71 | nM | 7.97 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 14.21 | nM | 7.85 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 15.55 | nM | 7.81 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 16.93 | nM | 7.77 |
| CHEMBL513909 | BI-2536 | IC50 | = | 17.05 | nM | 7.77 |
| CHEMBL514499 | GW843682X | IC50 | = | 18.15 | nM | 7.74 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 20.35 | nM | 7.69 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 23.68 | nM | 7.63 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 29.27 | nM | 7.53 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 44.91 | nM | 7.35 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 107.61 | nM | 6.97 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 122.29 | nM | 6.91 |
| CHEMBL300389 | — | IC50 | = | 170.05 | nM | 6.77 |
| CHEMBL379300 | A-443654 | IC50 | = | 177.07 | nM | 6.75 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 213.15 | nM | 6.67 |
| CHEMBL379975 | — | IC50 | = | 212.98 | nM | 6.67 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 233.83 | nM | 6.63 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 291.15 | nM | 6.54 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 292.27 | nM | 6.53 |
| CHEMBL213100 | — | IC50 | = | 371.63 | nM | 6.43 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 401.31 | nM | 6.40 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 403.35 | nM | 6.39 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 456.96 | nM | 6.34 |
| CHEMBL217354 | — | IC50 | = | 466.96 | nM | 6.33 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 466.71 | nM | 6.33 |
| CHEMBL585951 | — | IC50 | = | 473.45 | nM | 6.33 |
| CHEMBL401930 | — | IC50 | = | 490.05 | nM | 6.31 |
| CHEMBL197603 | — | IC50 | = | 695.51 | nM | 6.16 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 759.99 | nM | 6.12 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 793.03 | nM | 6.10 |
| CHEMBL202721 | — | IC50 | = | 836.35 | nM | 6.08 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 863.16 | nM | 6.06 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 896.45 | nM | 6.05 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 929.41 | nM | 6.03 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1139.51 | nM | 5.94 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1195.67 | nM | 5.92 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1202.14 | nM | 5.92 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1259.11 | nM | 5.90 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1340.48 | nM | 5.87 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1550.07 | nM | 5.81 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1884.18 | nM | 5.72 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1963.11 | nM | 5.71 |