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Assay Detail

CHEMBL2363697

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Functional
SANGER: Inhibition of human SW982 cell growth in a cell viability assay.
ChEMBL ↗
124
Total Activities
123
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW982
Confidence 1 — Organism
Curated By Autocuration

Target

SW982 (CHEMBL2366238) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 124 6.04 9.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 9.67
CHEMBL96926 THAPSIGARGIN — 1 9.33
CHEMBL94657 PATUPILONE 3.0 1 9.00
CHEMBL3545252 DOCETAXEL 4.0 1 8.90
CHEMBL65 CAMPTOTHECIN -1.0 1 8.39
CHEMBL553025 VINORELBINE 4.0 1 8.28
CHEMBL53463 DOXORUBICIN 4.0 1 8.22
CHEMBL1972860 ELESCLOMOL 3.0 1 8.13
CHEMBL428647 PACLITAXEL 4.0 1 8.12
CHEMBL159 VINBLASTINE 4.0 1 8.05
CHEMBL5416410 DASATINIB 4.0 1 7.95
CHEMBL252164 LUMINESPIB 2.0 1 7.89
CHEMBL514499 GW843682X — 1 7.60
CHEMBL300389 — — 1 7.59
CHEMBL109480 TANESPIMYCIN 3.0 1 7.52
CHEMBL2165191 AZD-6482 2.0 2 7.45
CHEMBL513909 BI-2536 2.0 1 7.42
CHEMBL1256459 TORIN1 — 1 7.37
CHEMBL603469 LESTAURTINIB 3.0 1 7.37
CHEMBL608533 MIDOSTAURIN 4.0 1 7.34
CHEMBL1879463 DACTOLISIB 3.0 1 7.30
CHEMBL9470 SHIKONIN — 1 7.22
CHEMBL803 CYTARABINE 4.0 1 7.04
CHEMBL105 MITOMYCIN 4.0 1 6.98
CHEMBL217354 — — 1 6.96
CHEMBL585951 — — 1 6.92
CHEMBL44657 ETOPOSIDE 4.0 1 6.88
CHEMBL509032 TAE-684 — 1 6.78
CHEMBL379300 A-443654 — 1 6.78
CHEMBL572878 TOZASERTIB 2.0 1 6.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.2133 nM 9.67
CHEMBL96926 THAPSIGARGIN IC50 = 0.472 nM 9.33
CHEMBL94657 PATUPILONE IC50 = 0.9994 nM 9.00
CHEMBL3545252 DOCETAXEL IC50 = 1.27 nM 8.90
CHEMBL65 CAMPTOTHECIN IC50 = 4.062 nM 8.39
CHEMBL553025 VINORELBINE IC50 = 5.298 nM 8.28
CHEMBL53463 DOXORUBICIN IC50 = 6.051 nM 8.22
CHEMBL1972860 ELESCLOMOL IC50 = 7.44 nM 8.13
CHEMBL428647 PACLITAXEL IC50 = 7.66 nM 8.12
CHEMBL159 VINBLASTINE IC50 = 8.919 nM 8.05
CHEMBL5416410 DASATINIB IC50 = 11.15 nM 7.95
CHEMBL252164 LUMINESPIB IC50 = 12.93 nM 7.89
CHEMBL514499 GW843682X IC50 = 25.25 nM 7.60
CHEMBL300389 — IC50 = 25.39 nM 7.59
CHEMBL109480 TANESPIMYCIN IC50 = 29.99 nM 7.52
CHEMBL2165191 AZD-6482 IC50 = 35.84 nM 7.45
CHEMBL513909 BI-2536 IC50 = 37.9 nM 7.42
CHEMBL1256459 TORIN1 IC50 = 42.46 nM 7.37
CHEMBL603469 LESTAURTINIB IC50 = 42.46 nM 7.37
CHEMBL608533 MIDOSTAURIN IC50 = 45.58 nM 7.34
CHEMBL1879463 DACTOLISIB IC50 = 49.91 nM 7.30
CHEMBL9470 SHIKONIN IC50 = 60.23 nM 7.22
CHEMBL803 CYTARABINE IC50 = 91.23 nM 7.04
CHEMBL105 MITOMYCIN IC50 = 104.73 nM 6.98
CHEMBL217354 — IC50 = 110.7 nM 6.96
CHEMBL585951 — IC50 = 121.0 nM 6.92
CHEMBL44657 ETOPOSIDE IC50 = 130.69 nM 6.88
CHEMBL509032 TAE-684 IC50 = 164.78 nM 6.78
CHEMBL379300 A-443654 IC50 = 166.3 nM 6.78
CHEMBL572878 TOZASERTIB IC50 = 213.8 nM 6.67
CHEMBL412142 LADUVIGLUSIB IC50 = 214.16 nM 6.67
CHEMBL1171837 PONATINIB IC50 = 299.78 nM 6.52
CHEMBL413 SIROLIMUS IC50 = 314.75 nM 6.50
CHEMBL1084546 PF-00562271 IC50 = 328.2 nM 6.48
CHEMBL197603 — IC50 = 386.8 nM 6.41
CHEMBL6067492 BLEOMYCIN IC50 = 417.43 nM 6.38
CHEMBL449158 BRYOSTATIN 1 IC50 = 424.91 nM 6.37
CHEMBL3349342 — IC50 = 436.37 nM 6.36
CHEMBL1201182 TEMSIROLIMUS IC50 = 440.68 nM 6.36
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 445.28 nM 6.35
CHEMBL575448 BMS-754807 IC50 = 478.69 nM 6.32
CHEMBL1801204 AZD-8055 IC50 = 685.01 nM 6.16
CHEMBL401930 — IC50 = 717.95 nM 6.14
CHEMBL2041933 AZD-7762 IC50 = 784.32 nM 6.11
CHEMBL1190711 — IC50 = 774.61 nM 6.11
CHEMBL213100 — IC50 = 858.19 nM 6.07
CHEMBL577784 BX-795 IC50 = 951.24 nM 6.02
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1067.66 nM 5.97
CHEMBL515416 — IC50 = 1310.8 nM 5.88
CHEMBL191384 — IC50 = 1776.26 nM 5.75