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Assay Detail

CHEMBL2363718

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Functional
SANGER: Inhibition of human 8505C cell growth in a cell viability assay.
ChEMBL ↗
98
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 8505C
Confidence 1 — Organism
Curated By Autocuration

Target

8505C (CHEMBL1075387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 98 5.73 10.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 10.12
CHEMBL94657 PATUPILONE 3.0 1 9.35
CHEMBL3545252 DOCETAXEL 4.0 1 9.07
CHEMBL888 GEMCITABINE 4.0 1 8.97
CHEMBL159 VINBLASTINE 4.0 1 8.51
CHEMBL65 CAMPTOTHECIN -1.0 1 8.48
CHEMBL553025 VINORELBINE 4.0 1 8.36
CHEMBL252164 LUMINESPIB 2.0 1 8.09
CHEMBL1972860 ELESCLOMOL 3.0 1 7.98
CHEMBL53463 DOXORUBICIN 4.0 1 7.71
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.52
CHEMBL1879463 DACTOLISIB 3.0 1 7.43
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.43
CHEMBL217354 — — 1 6.66
CHEMBL507361 MIRDAMETINIB 2.0 1 6.65
CHEMBL608533 MIDOSTAURIN 4.0 1 6.56
CHEMBL603469 LESTAURTINIB 3.0 1 6.52
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.49
CHEMBL2041933 AZD-7762 1.0 1 6.46
CHEMBL289228 TIPIFARNIB 3.0 1 6.37
CHEMBL105 MITOMYCIN 4.0 1 6.37
CHEMBL44657 ETOPOSIDE 4.0 1 6.16
CHEMBL1171837 PONATINIB 4.0 1 6.14
CHEMBL109480 TANESPIMYCIN 3.0 1 6.00
CHEMBL98 VORINOSTAT 4.0 1 5.99
CHEMBL6067492 BLEOMYCIN 4.0 1 5.98
CHEMBL585951 — — 1 5.90
CHEMBL1801204 AZD-8055 1.0 1 5.89
CHEMBL575448 BMS-754807 2.0 1 5.87
CHEMBL1190711 — — 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 0.0762 nM 10.12
CHEMBL94657 PATUPILONE IC50 = 0.4507 nM 9.35
CHEMBL3545252 DOCETAXEL IC50 = 0.8535 nM 9.07
CHEMBL888 GEMCITABINE IC50 = 1.063 nM 8.97
CHEMBL159 VINBLASTINE IC50 = 3.109 nM 8.51
CHEMBL65 CAMPTOTHECIN IC50 = 3.301 nM 8.48
CHEMBL553025 VINORELBINE IC50 = 4.419 nM 8.36
CHEMBL252164 LUMINESPIB IC50 = 8.214 nM 8.09
CHEMBL1972860 ELESCLOMOL IC50 = 10.53 nM 7.98
CHEMBL53463 DOXORUBICIN IC50 = 19.56 nM 7.71
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 30.4 nM 7.52
CHEMBL1879463 DACTOLISIB IC50 = 37.51 nM 7.43
CHEMBL449158 BRYOSTATIN 1 IC50 = 36.8 nM 7.43
CHEMBL217354 — IC50 = 221.29 nM 6.66
CHEMBL507361 MIRDAMETINIB IC50 = 224.39 nM 6.65
CHEMBL608533 MIDOSTAURIN IC50 = 276.04 nM 6.56
CHEMBL603469 LESTAURTINIB IC50 = 302.14 nM 6.52
CHEMBL1201182 TEMSIROLIMUS IC50 = 326.14 nM 6.49
CHEMBL2041933 AZD-7762 IC50 = 350.02 nM 6.46
CHEMBL289228 TIPIFARNIB IC50 = 431.09 nM 6.37
CHEMBL105 MITOMYCIN IC50 = 429.83 nM 6.37
CHEMBL44657 ETOPOSIDE IC50 = 692.75 nM 6.16
CHEMBL1171837 PONATINIB IC50 = 727.41 nM 6.14
CHEMBL109480 TANESPIMYCIN IC50 = 999.82 nM 6.00
CHEMBL98 VORINOSTAT IC50 = 1023.31 nM 5.99
CHEMBL6067492 BLEOMYCIN IC50 = 1039.98 nM 5.98
CHEMBL585951 — IC50 = 1261.34 nM 5.90
CHEMBL1801204 AZD-8055 IC50 = 1288.23 nM 5.89
CHEMBL575448 BMS-754807 IC50 = 1359.94 nM 5.87
CHEMBL1190711 — IC50 = 1770.46 nM 5.75
CHEMBL3349342 — IC50 = 2576.96 nM 5.59
CHEMBL2363137 — IC50 = 2666.0 nM 5.57
CHEMBL191384 — IC50 = 2899.85 nM 5.54
CHEMBL288441 BOSUTINIB IC50 = 3103.01 nM 5.51
CHEMBL9470 SHIKONIN IC50 = 3099.47 nM 5.51
CHEMBL803 CYTARABINE IC50 = 3702.01 nM 5.43
CHEMBL577784 BX-795 IC50 = 3797.68 nM 5.42
CHEMBL105442 CI-1040 IC50 = 3900.78 nM 5.41
CHEMBL591429 PAC-1 IC50 = 4407.68 nM 5.36
CHEMBL573107 — IC50 = 4458.25 nM 5.35
CHEMBL259181 — IC50 = 4568.47 nM 5.34
CHEMBL443684 NAVITOCLAX IC50 = 4542.3 nM 5.34
CHEMBL189963 PALBOCICLIB IC50 = 6075.73 nM 5.22
CHEMBL558642 GSK-650394 IC50 = 7782.4 nM 5.11
CHEMBL393929 — IC50 = 7998.17 nM 5.10
CHEMBL202721 — IC50 = 8357.34 nM 5.08
CHEMBL1289926 AXITINIB IC50 = 8648.24 nM 5.06
CHEMBL1079175 MK-2206 IC50 = 9042.32 nM 5.04
CHEMBL477989 SB590885 IC50 = 11158.71 nM 4.95
CHEMBL472940 — IC50 = 11246.14 nM 4.95