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Assay Detail

CHEMBL2363720

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Functional
SANGER: Inhibition of human A172 cell growth in a cell viability assay.
ChEMBL ↗
90
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A 172
Confidence 1 — Organism
Curated By Autocuration

Target

A 172 (CHEMBL614512) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 90 5.57 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 9.60
CHEMBL3545252 DOCETAXEL 4.0 1 8.79
CHEMBL94657 PATUPILONE 3.0 1 8.72
CHEMBL159 VINBLASTINE 4.0 1 8.02
CHEMBL65 CAMPTOTHECIN -1.0 1 7.89
CHEMBL553025 VINORELBINE 4.0 1 7.86
CHEMBL1972860 ELESCLOMOL 3.0 1 7.68
CHEMBL888 GEMCITABINE 4.0 1 7.61
CHEMBL252164 LUMINESPIB 2.0 1 7.40
CHEMBL53463 DOXORUBICIN 4.0 1 7.09
CHEMBL188678 — — 1 6.82
CHEMBL109480 TANESPIMYCIN 3.0 1 6.68
CHEMBL608533 MIDOSTAURIN 4.0 1 6.54
CHEMBL1171837 PONATINIB 4.0 1 6.53
CHEMBL9470 SHIKONIN — 1 6.33
CHEMBL573107 — — 1 6.29
CHEMBL105 MITOMYCIN 4.0 1 6.27
CHEMBL585951 — — 1 6.17
CHEMBL2041933 AZD-7762 1.0 1 6.16
CHEMBL217354 — — 1 6.10
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.05
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.01
CHEMBL202721 — — 1 6.01
CHEMBL1201182 TEMSIROLIMUS 4.0 1 5.94
CHEMBL575448 BMS-754807 2.0 1 5.82
CHEMBL189584 PD-173074 — 1 5.77
CHEMBL34259 METHOTREXATE 4.0 1 5.72
CHEMBL603469 LESTAURTINIB 3.0 1 5.71
CHEMBL191384 — — 1 5.67
CHEMBL1289926 AXITINIB 4.0 1 5.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 0.2543 nM 9.60
CHEMBL3545252 DOCETAXEL IC50 = 1.628 nM 8.79
CHEMBL94657 PATUPILONE IC50 = 1.924 nM 8.72
CHEMBL159 VINBLASTINE IC50 = 9.616 nM 8.02
CHEMBL65 CAMPTOTHECIN IC50 = 12.76 nM 7.89
CHEMBL553025 VINORELBINE IC50 = 13.92 nM 7.86
CHEMBL1972860 ELESCLOMOL IC50 = 20.89 nM 7.68
CHEMBL888 GEMCITABINE IC50 = 24.71 nM 7.61
CHEMBL252164 LUMINESPIB IC50 = 39.5 nM 7.40
CHEMBL53463 DOXORUBICIN IC50 = 80.55 nM 7.09
CHEMBL188678 — IC50 = 153.16 nM 6.82
CHEMBL109480 TANESPIMYCIN IC50 = 210.22 nM 6.68
CHEMBL608533 MIDOSTAURIN IC50 = 291.5 nM 6.54
CHEMBL1171837 PONATINIB IC50 = 295.77 nM 6.53
CHEMBL9470 SHIKONIN IC50 = 469.75 nM 6.33
CHEMBL573107 — IC50 = 517.05 nM 6.29
CHEMBL105 MITOMYCIN IC50 = 537.52 nM 6.27
CHEMBL585951 — IC50 = 668.98 nM 6.17
CHEMBL2041933 AZD-7762 IC50 = 692.17 nM 6.16
CHEMBL217354 — IC50 = 793.83 nM 6.10
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 886.98 nM 6.05
CHEMBL449158 BRYOSTATIN 1 IC50 = 975.66 nM 6.01
CHEMBL202721 — IC50 = 984.11 nM 6.01
CHEMBL1201182 TEMSIROLIMUS IC50 = 1156.53 nM 5.94
CHEMBL575448 BMS-754807 IC50 = 1527.21 nM 5.82
CHEMBL189584 PD-173074 IC50 = 1703.55 nM 5.77
CHEMBL34259 METHOTREXATE IC50 = 1895.89 nM 5.72
CHEMBL603469 LESTAURTINIB IC50 = 1944.99 nM 5.71
CHEMBL191384 — IC50 = 2157.46 nM 5.67
CHEMBL1289926 AXITINIB IC50 = 2136.06 nM 5.67
CHEMBL1190711 — IC50 = 2219.36 nM 5.65
CHEMBL191334 NUTLIN-3 IC50 = 2675.88 nM 5.57
CHEMBL803 CYTARABINE IC50 = 3517.8 nM 5.45
CHEMBL477772 PAZOPANIB IC50 = 3737.9 nM 5.43
CHEMBL412142 LADUVIGLUSIB IC50 = 3754.98 nM 5.42
CHEMBL577784 BX-795 IC50 = 4445.7 nM 5.35
CHEMBL939 GEFITINIB IC50 = 4555.21 nM 5.34
CHEMBL240954 — IC50 = 4771.72 nM 5.32
CHEMBL288441 BOSUTINIB IC50 = 5549.25 nM 5.26
CHEMBL135561 — IC50 = 5670.54 nM 5.25
CHEMBL393929 — IC50 = 5907.9 nM 5.23
CHEMBL2363137 — IC50 = 5912.46 nM 5.23
CHEMBL259181 — IC50 = 6157.45 nM 5.21
CHEMBL105442 CI-1040 IC50 = 6491.76 nM 5.19
CHEMBL399530 — IC50 = 7347.33 nM 5.13
CHEMBL98 VORINOSTAT IC50 = 7861.72 nM 5.10
CHEMBL44657 ETOPOSIDE IC50 = 8649.64 nM 5.06
CHEMBL221137 EMBELIN IC50 = 8775.31 nM 5.06
CHEMBL289228 TIPIFARNIB IC50 = 10127.17 nM 5.00
CHEMBL1084546 PF-00562271 IC50 = 12120.68 nM 4.92