Assay Detail
Functional
CHEMBL2363728
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SANGER: Inhibition of human A4-Fuk cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A4-Fuk |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 6.03 | 10.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 10.29 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.21 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.20 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.96 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.76 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.73 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.41 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.39 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.24 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.21 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.88 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.88 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.77 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 7.69 |
| CHEMBL514499 | GW843682X | — | 1 | 7.68 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.65 |
| CHEMBL300389 | — | — | 1 | 7.55 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.55 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.42 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.33 |
| CHEMBL509032 | TAE-684 | — | 1 | 7.25 |
| CHEMBL401930 | — | — | 1 | 7.24 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.13 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.09 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.05 |
| CHEMBL379300 | A-443654 | — | 1 | 6.99 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.97 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.94 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.05177 | nM | 10.29 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.6229 | nM | 9.21 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.6263 | nM | 9.20 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.749 | nM | 8.76 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 1.867 | nM | 8.73 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.035 | nM | 8.39 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.109 | nM | 8.21 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 13.12 | nM | 7.88 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 13.19 | nM | 7.88 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.02 | nM | 7.77 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 20.59 | nM | 7.69 |
| CHEMBL514499 | GW843682X | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL513909 | BI-2536 | IC50 | = | 22.18 | nM | 7.65 |
| CHEMBL300389 | — | IC50 | = | 27.99 | nM | 7.55 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 28.06 | nM | 7.55 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 38.23 | nM | 7.42 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 46.52 | nM | 7.33 |
| CHEMBL509032 | TAE-684 | IC50 | = | 55.65 | nM | 7.25 |
| CHEMBL401930 | — | IC50 | = | 57.75 | nM | 7.24 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 74.86 | nM | 7.13 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 81.82 | nM | 7.09 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 82.67 | nM | 7.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 89.47 | nM | 7.05 |
| CHEMBL379300 | A-443654 | IC50 | = | 102.54 | nM | 6.99 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 107.61 | nM | 6.97 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 115.63 | nM | 6.94 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 162.48 | nM | 6.79 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 225.43 | nM | 6.65 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 249.73 | nM | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 289.04 | nM | 6.54 |
| CHEMBL939 | GEFITINIB | IC50 | = | 350.02 | nM | 6.46 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 452.92 | nM | 6.34 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 468.68 | nM | 6.33 |
| CHEMBL2144069 | — | IC50 | = | 483.75 | nM | 6.32 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 525.28 | nM | 6.28 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 560.48 | nM | 6.25 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 644.91 | nM | 6.19 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 841.03 | nM | 6.08 |
| CHEMBL585951 | — | IC50 | = | 972.49 | nM | 6.01 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1153.64 | nM | 5.94 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1173.49 | nM | 5.93 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1204.41 | nM | 5.92 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1299.93 | nM | 5.89 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1307.04 | nM | 5.88 |
| CHEMBL535 | SUNITINIB | IC50 | = | 1341.41 | nM | 5.87 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1570.45 | nM | 5.80 |
| CHEMBL209148 | — | IC50 | = | 1617.88 | nM | 5.79 |