Assay Detail
Functional
CHEMBL2363729
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SANGER: Inhibition of human A427 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-427 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.86 | 9.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 9.93 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.08 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.83 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.67 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.51 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.37 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.93 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.90 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.89 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.75 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.63 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.46 |
| CHEMBL217354 | — | — | 1 | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.99 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.92 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.74 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.74 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.70 |
| CHEMBL2363137 | — | — | 1 | 6.64 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.61 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.56 |
| CHEMBL585951 | — | — | 1 | 6.54 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.52 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.49 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.38 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.25 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.24 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 0.118 | nM | 9.93 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.8277 | nM | 9.08 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.485 | nM | 8.83 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 2.124 | nM | 8.67 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.103 | nM | 8.51 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.251 | nM | 8.37 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 6.067 | nM | 8.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 11.81 | nM | 7.93 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.55 | nM | 7.90 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.99 | nM | 7.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 17.99 | nM | 7.75 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 23.41 | nM | 7.63 |
| CHEMBL803 | CYTARABINE | IC50 | = | 34.49 | nM | 7.46 |
| CHEMBL217354 | — | IC50 | = | 44.69 | nM | 7.35 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 85.12 | nM | 7.07 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 103.38 | nM | 6.99 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 119.18 | nM | 6.92 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 182.67 | nM | 6.74 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 182.57 | nM | 6.74 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 198.32 | nM | 6.70 |
| CHEMBL2363137 | — | IC50 | = | 230.04 | nM | 6.64 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 243.22 | nM | 6.61 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 272.64 | nM | 6.56 |
| CHEMBL585951 | — | IC50 | = | 286.12 | nM | 6.54 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 301.33 | nM | 6.52 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 323.98 | nM | 6.49 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 419.81 | nM | 6.38 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 566.56 | nM | 6.25 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 579.17 | nM | 6.24 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 833.04 | nM | 6.08 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 920.84 | nM | 6.04 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 930.22 | nM | 6.03 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 961.98 | nM | 6.02 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 995.05 | nM | 6.00 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1103.81 | nM | 5.96 |
| CHEMBL577784 | BX-795 | IC50 | = | 1735.89 | nM | 5.76 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1876.11 | nM | 5.73 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 1980.75 | nM | 5.70 |
| CHEMBL573107 | — | IC50 | = | 3108.73 | nM | 5.51 |
| CHEMBL258844 | — | IC50 | = | 3076.93 | nM | 5.51 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 3256.99 | nM | 5.49 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3461.24 | nM | 5.46 |
| CHEMBL105442 | CI-1040 | IC50 | = | 3595.56 | nM | 5.44 |
| CHEMBL3349342 | — | IC50 | = | 4460.75 | nM | 5.35 |
| CHEMBL1190711 | — | IC50 | = | 4604.57 | nM | 5.34 |
| CHEMBL202721 | — | IC50 | = | 4645.55 | nM | 5.33 |
| CHEMBL477989 | SB590885 | IC50 | = | 5330.74 | nM | 5.27 |
| CHEMBL188678 | — | IC50 | = | 5536.61 | nM | 5.26 |
| CHEMBL2134202 | — | IC50 | = | 5725.67 | nM | 5.24 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 5972.52 | nM | 5.22 |