Assay Detail
Functional
CHEMBL2363731
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SANGER: Inhibition of human A498 cell growth in a cell viability assay.
133
Total Activities
131
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A498 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 133 | 5.56 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.55 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.15 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.58 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.33 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.21 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.14 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.09 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.99 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.99 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.93 |
| CHEMBL585951 | — | — | 1 | 6.77 |
| CHEMBL213100 | — | — | 1 | 6.72 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.66 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.65 |
| CHEMBL300389 | — | — | 1 | 6.45 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.39 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.36 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.32 |
| CHEMBL135561 | — | — | 1 | 5.97 |
| CHEMBL258844 | — | — | 1 | 5.97 |
| CHEMBL514499 | GW843682X | — | 1 | 5.94 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.92 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 5.88 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.88 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.85 |
| CHEMBL217354 | — | — | 1 | 5.83 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.76 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.2784 | nM | 9.55 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.938 | nM | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.077 | nM | 8.15 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 26.21 | nM | 7.58 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 46.55 | nM | 7.33 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 72.84 | nM | 7.14 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 75.15 | nM | 7.12 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 81.9 | nM | 7.09 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 101.8 | nM | 6.99 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 102.79 | nM | 6.99 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 117.95 | nM | 6.93 |
| CHEMBL585951 | — | IC50 | = | 170.66 | nM | 6.77 |
| CHEMBL213100 | — | IC50 | = | 189.45 | nM | 6.72 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 221.47 | nM | 6.66 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 221.86 | nM | 6.65 |
| CHEMBL300389 | — | IC50 | = | 359.13 | nM | 6.45 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 406.74 | nM | 6.39 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 440.76 | nM | 6.36 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 459.35 | nM | 6.34 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 476.93 | nM | 6.32 |
| CHEMBL135561 | — | IC50 | = | 1059.39 | nM | 5.97 |
| CHEMBL258844 | — | IC50 | = | 1081.34 | nM | 5.97 |
| CHEMBL514499 | GW843682X | IC50 | = | 1154.67 | nM | 5.94 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1215.34 | nM | 5.92 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 1304.69 | nM | 5.88 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1304.74 | nM | 5.88 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1401.13 | nM | 5.85 |
| CHEMBL217354 | — | IC50 | = | 1494.73 | nM | 5.83 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1729.63 | nM | 5.76 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1812.82 | nM | 5.74 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2294.15 | nM | 5.64 |
| CHEMBL202721 | — | IC50 | = | 2366.9 | nM | 5.63 |
| CHEMBL941 | IMATINIB | IC50 | = | 2572.23 | nM | 5.59 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3208.71 | nM | 5.49 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3729.49 | nM | 5.43 |
| CHEMBL577784 | BX-795 | IC50 | = | 4563.83 | nM | 5.34 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 4605.11 | nM | 5.34 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 5212.51 | nM | 5.28 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 6084.73 | nM | 5.22 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 6403.02 | nM | 5.19 |
| CHEMBL401930 | — | IC50 | = | 6687.93 | nM | 5.17 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 6819.61 | nM | 5.17 |
| CHEMBL513909 | BI-2536 | IC50 | = | 6871.92 | nM | 5.16 |
| CHEMBL176544 | — | IC50 | = | 7687.13 | nM | 5.11 |
| CHEMBL483847 | — | IC50 | = | 8221.86 | nM | 5.08 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 8284.46 | nM | 5.08 |
| CHEMBL1673039 | — | IC50 | = | 8225.36 | nM | 5.08 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 8784.75 | nM | 5.06 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9373.67 | nM | 5.03 |