Assay Detail
Functional
CHEMBL2363738
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SANGER: Inhibition of human AGS cell growth in a cell viability assay.
96
Total Activities
95
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AGS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 96 | 5.99 | 10.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.04 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.59 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.54 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.48 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.19 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.06 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.91 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.88 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.79 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.71 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.69 |
| CHEMBL217354 | — | — | 1 | 7.43 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.31 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.16 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.98 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.93 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 6.82 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.76 |
| CHEMBL3349342 | — | — | 1 | 6.62 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.60 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.50 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.41 |
| CHEMBL585951 | — | — | 1 | 6.38 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.30 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.24 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.21 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.08 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.09016 | nM | 10.04 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2.577 | nM | 8.59 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.863 | nM | 8.54 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.277 | nM | 8.48 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.462 | nM | 8.19 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.778 | nM | 8.06 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.61 | nM | 7.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 13.27 | nM | 7.88 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 14.11 | nM | 7.85 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 16.13 | nM | 7.79 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 19.38 | nM | 7.71 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 20.41 | nM | 7.69 |
| CHEMBL217354 | — | IC50 | = | 37.53 | nM | 7.43 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 48.77 | nM | 7.31 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 69.09 | nM | 7.16 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 105.8 | nM | 6.98 |
| CHEMBL105442 | CI-1040 | IC50 | = | 117.13 | nM | 6.93 |
| CHEMBL1090090 | VX-702 | IC50 | = | 152.51 | nM | 6.82 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 173.52 | nM | 6.76 |
| CHEMBL3349342 | — | IC50 | = | 239.74 | nM | 6.62 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 250.08 | nM | 6.60 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 318.23 | nM | 6.50 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 386.38 | nM | 6.41 |
| CHEMBL585951 | — | IC50 | = | 414.88 | nM | 6.38 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 502.53 | nM | 6.30 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 581.62 | nM | 6.24 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 612.57 | nM | 6.21 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 836.48 | nM | 6.08 |
| CHEMBL803 | CYTARABINE | IC50 | = | 917.55 | nM | 6.04 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1094.59 | nM | 5.96 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1113.95 | nM | 5.95 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1118.31 | nM | 5.95 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1168.17 | nM | 5.93 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1521.24 | nM | 5.82 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1763.58 | nM | 5.75 |
| CHEMBL573107 | — | IC50 | = | 2344.04 | nM | 5.63 |
| CHEMBL577784 | BX-795 | IC50 | = | 2562.57 | nM | 5.59 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2721.37 | nM | 5.57 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3624.64 | nM | 5.44 |
| CHEMBL202721 | — | IC50 | = | 4033.84 | nM | 5.39 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4533.23 | nM | 5.34 |
| CHEMBL399530 | — | IC50 | = | 4700.04 | nM | 5.33 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 5365.57 | nM | 5.27 |
| CHEMBL2363137 | — | IC50 | = | 5365.64 | nM | 5.27 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5496.18 | nM | 5.26 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 6148.28 | nM | 5.21 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 6382.91 | nM | 5.20 |
| CHEMBL259181 | — | IC50 | = | 6711.36 | nM | 5.17 |
| CHEMBL258844 | — | IC50 | = | 7563.27 | nM | 5.12 |