Assay Detail
Functional
CHEMBL2363739
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SANGER: Inhibition of human ALL-PO cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ALL-PO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.80 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.83 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.81 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.47 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.28 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.23 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL514499 | GW843682X | — | 1 | 8.06 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.06 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.89 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.79 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.76 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.51 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.50 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.30 |
| CHEMBL512504 | — | — | 1 | 7.24 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 7.20 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.19 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.11 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.10 |
| CHEMBL300389 | — | — | 1 | 7.10 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.91 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.84 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.76 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.62 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.62 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.61 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.54 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.50 |
| CHEMBL401930 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.469 | nM | 8.83 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.534 | nM | 8.81 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 3.359 | nM | 8.47 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.215 | nM | 8.28 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 5.858 | nM | 8.23 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.298 | nM | 8.20 |
| CHEMBL514499 | GW843682X | IC50 | = | 8.759 | nM | 8.06 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 8.602 | nM | 8.06 |
| CHEMBL513909 | BI-2536 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 16.26 | nM | 7.79 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.35 | nM | 7.76 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 30.98 | nM | 7.51 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 31.84 | nM | 7.50 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 49.56 | nM | 7.30 |
| CHEMBL512504 | — | IC50 | = | 57.93 | nM | 7.24 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 63.55 | nM | 7.20 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 65.03 | nM | 7.19 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 77.66 | nM | 7.11 |
| CHEMBL535 | SUNITINIB | IC50 | = | 79.89 | nM | 7.10 |
| CHEMBL300389 | — | IC50 | = | 80.03 | nM | 7.10 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 124.43 | nM | 6.91 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 145.46 | nM | 6.84 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 171.6 | nM | 6.76 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 219.88 | nM | 6.66 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 242.43 | nM | 6.62 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 241.69 | nM | 6.62 |
| CHEMBL509032 | TAE-684 | IC50 | = | 245.24 | nM | 6.61 |
| CHEMBL803 | CYTARABINE | IC50 | = | 287.09 | nM | 6.54 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 315.12 | nM | 6.50 |
| CHEMBL401930 | — | IC50 | = | 372.58 | nM | 6.43 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 415.69 | nM | 6.38 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 554.56 | nM | 6.26 |
| CHEMBL1190711 | — | IC50 | = | 557.2 | nM | 6.25 |
| CHEMBL585951 | — | IC50 | = | 671.46 | nM | 6.17 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 689.79 | nM | 6.16 |
| CHEMBL379300 | A-443654 | IC50 | = | 796.71 | nM | 6.10 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 807.9 | nM | 6.09 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 805.3 | nM | 6.09 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 814.66 | nM | 6.09 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 812.77 | nM | 6.09 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 881.75 | nM | 6.05 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 986.27 | nM | 6.01 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1015.84 | nM | 5.99 |
| CHEMBL577784 | BX-795 | IC50 | = | 1060.73 | nM | 5.97 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 1185.44 | nM | 5.93 |
| CHEMBL2144069 | — | IC50 | = | 1348.69 | nM | 5.87 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1437.74 | nM | 5.84 |
| CHEMBL191384 | — | IC50 | = | 1790.72 | nM | 5.75 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1800.15 | nM | 5.75 |
| CHEMBL393929 | — | IC50 | = | 1908.13 | nM | 5.72 |