Assay Detail
Functional
CHEMBL2363744
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SANGER: Inhibition of human AU565 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AU565 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.71 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.92 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.74 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.46 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.43 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.39 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.09 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.66 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.23 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.21 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.07 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.98 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.93 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.67 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.65 |
| CHEMBL585951 | — | — | 1 | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.49 |
| CHEMBL217354 | — | — | 1 | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.37 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.30 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.08 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.06 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.94 |
| CHEMBL258844 | — | — | 1 | 5.91 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.91 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.88 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.78 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.75 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.69 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.69 |
| CHEMBL2363137 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.202 | nM | 8.92 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.808 | nM | 8.74 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3.448 | nM | 8.46 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 3.68 | nM | 8.43 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.095 | nM | 8.39 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.185 | nM | 8.09 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 21.83 | nM | 7.66 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 59.07 | nM | 7.23 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 61.34 | nM | 7.21 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 85.04 | nM | 7.07 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 104.51 | nM | 6.98 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 118.31 | nM | 6.93 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 212.82 | nM | 6.67 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 224.43 | nM | 6.65 |
| CHEMBL585951 | — | IC50 | = | 285.49 | nM | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 321.11 | nM | 6.49 |
| CHEMBL217354 | — | IC50 | = | 352.65 | nM | 6.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 424.68 | nM | 6.37 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 500.96 | nM | 6.30 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 824.4 | nM | 6.08 |
| CHEMBL939 | GEFITINIB | IC50 | = | 869.6 | nM | 6.06 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1159.73 | nM | 5.94 |
| CHEMBL258844 | — | IC50 | = | 1239.17 | nM | 5.91 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1239.81 | nM | 5.91 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1318.63 | nM | 5.88 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1653.57 | nM | 5.78 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1794.89 | nM | 5.75 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2054.02 | nM | 5.69 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2059.05 | nM | 5.69 |
| CHEMBL2363137 | — | IC50 | = | 2343.0 | nM | 5.63 |
| CHEMBL255342 | — | IC50 | = | 2344.46 | nM | 5.63 |
| CHEMBL191384 | — | IC50 | = | 2552.51 | nM | 5.59 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2611.26 | nM | 5.58 |
| CHEMBL803 | CYTARABINE | IC50 | = | 3470.21 | nM | 5.46 |
| CHEMBL591429 | PAC-1 | IC50 | = | 3854.97 | nM | 5.41 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5097.02 | nM | 5.29 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 5548.49 | nM | 5.26 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 5991.49 | nM | 5.22 |
| CHEMBL399530 | — | IC50 | = | 5953.01 | nM | 5.22 |
| CHEMBL259181 | — | IC50 | = | 6473.53 | nM | 5.19 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 6969.57 | nM | 5.16 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 7103.72 | nM | 5.15 |
| CHEMBL1190711 | — | IC50 | = | 7146.06 | nM | 5.15 |
| CHEMBL188678 | — | IC50 | = | 7598.33 | nM | 5.12 |
| CHEMBL221137 | EMBELIN | IC50 | = | 9909.27 | nM | 5.00 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 15209.56 | nM | 4.82 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 16153.57 | nM | 4.79 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 16759.78 | nM | 4.78 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 17038.63 | nM | 4.77 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 17225.04 | nM | 4.76 |