Assay Detail
Functional
CHEMBL2363778
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SANGER: Inhibition of human CAL-12T cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-12T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.62 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.89 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.62 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.96 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.43 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.87 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.68 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.41 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.25 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.20 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.04 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.59 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.58 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.55 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.43 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.37 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.36 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.31 |
| CHEMBL1190711 | — | — | 1 | 6.30 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.13 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.12 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.11 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.10 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.06 |
| CHEMBL2363137 | — | — | 1 | 5.99 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.97 |
| CHEMBL3349342 | — | — | 1 | 5.97 |
| CHEMBL217354 | — | — | 1 | 5.95 |
| CHEMBL191384 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.128 | nM | 9.89 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.2389 | nM | 9.62 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.084 | nM | 8.96 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.761 | nM | 8.43 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 9.225 | nM | 8.04 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 13.46 | nM | 7.87 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.65 | nM | 7.68 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 20.76 | nM | 7.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 55.97 | nM | 7.25 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 92.08 | nM | 7.04 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 258.51 | nM | 6.59 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 262.05 | nM | 6.58 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 280.01 | nM | 6.55 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 372.16 | nM | 6.43 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 427.8 | nM | 6.37 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 432.88 | nM | 6.36 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 491.25 | nM | 6.31 |
| CHEMBL1190711 | — | IC50 | = | 495.62 | nM | 6.30 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 738.77 | nM | 6.13 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 760.04 | nM | 6.12 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 780.29 | nM | 6.11 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 799.84 | nM | 6.10 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 870.15 | nM | 6.06 |
| CHEMBL2363137 | — | IC50 | = | 1024.29 | nM | 5.99 |
| CHEMBL3349342 | — | IC50 | = | 1069.27 | nM | 5.97 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1071.63 | nM | 5.97 |
| CHEMBL217354 | — | IC50 | = | 1121.48 | nM | 5.95 |
| CHEMBL191384 | — | IC50 | = | 1300.18 | nM | 5.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1902.22 | nM | 5.72 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1889.45 | nM | 5.72 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2018.61 | nM | 5.70 |
| CHEMBL585951 | — | IC50 | = | 2114.21 | nM | 5.67 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 2404.17 | nM | 5.62 |
| CHEMBL259181 | — | IC50 | = | 2479.88 | nM | 5.61 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 2711.58 | nM | 5.57 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 3407.13 | nM | 5.47 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 3962.12 | nM | 5.40 |
| CHEMBL573107 | — | IC50 | = | 4057.95 | nM | 5.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4131.03 | nM | 5.38 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4414.13 | nM | 5.36 |
| CHEMBL399530 | — | IC50 | = | 4525.69 | nM | 5.34 |
| CHEMBL577784 | BX-795 | IC50 | = | 4788.69 | nM | 5.32 |
| CHEMBL472940 | — | IC50 | = | 5641.4 | nM | 5.25 |
| CHEMBL379975 | — | IC50 | = | 7338.86 | nM | 5.13 |
| CHEMBL188678 | — | IC50 | = | 7943.52 | nM | 5.10 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8430.14 | nM | 5.07 |
| CHEMBL105442 | CI-1040 | IC50 | = | 8657.53 | nM | 5.06 |
| CHEMBL221137 | EMBELIN | IC50 | = | 9732.11 | nM | 5.01 |