Assay Detail
Functional
CHEMBL2363781
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SANGER: Inhibition of human CAL-33 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-33 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.63 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.98 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.82 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.72 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.22 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.21 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.65 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.51 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.36 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.17 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.07 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.75 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.70 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.56 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.43 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.29 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.27 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.16 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.14 |
| CHEMBL217354 | — | — | 1 | 6.09 |
| CHEMBL585951 | — | — | 1 | 6.08 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.06 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.01 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.95 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.93 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.92 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.83 |
| CHEMBL3349342 | — | — | 1 | 5.81 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.044 | nM | 8.98 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.515 | nM | 8.82 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.893 | nM | 8.72 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 5.021 | nM | 8.30 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.997 | nM | 8.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.184 | nM | 8.21 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 22.23 | nM | 7.65 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 30.66 | nM | 7.51 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 43.75 | nM | 7.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 67.87 | nM | 7.17 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 85.08 | nM | 7.07 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 157.25 | nM | 6.80 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 175.73 | nM | 6.75 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 201.84 | nM | 6.70 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 274.42 | nM | 6.56 |
| CHEMBL939 | GEFITINIB | IC50 | = | 370.9 | nM | 6.43 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 508.44 | nM | 6.29 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 536.53 | nM | 6.27 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 685.8 | nM | 6.16 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 729.9 | nM | 6.14 |
| CHEMBL217354 | — | IC50 | = | 816.62 | nM | 6.09 |
| CHEMBL585951 | — | IC50 | = | 826.06 | nM | 6.08 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 864.95 | nM | 6.06 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 983.78 | nM | 6.01 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1129.38 | nM | 5.95 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1176.22 | nM | 5.93 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1193.02 | nM | 5.92 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1488.79 | nM | 5.83 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1546.94 | nM | 5.81 |
| CHEMBL3349342 | — | IC50 | = | 1563.89 | nM | 5.81 |
| CHEMBL202721 | — | IC50 | = | 1726.0 | nM | 5.76 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 2000.04 | nM | 5.70 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2146.02 | nM | 5.67 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2553.47 | nM | 5.59 |
| CHEMBL258844 | — | IC50 | = | 3431.25 | nM | 5.46 |
| CHEMBL2363137 | — | IC50 | = | 3558.59 | nM | 5.45 |
| CHEMBL573107 | — | IC50 | = | 3533.62 | nM | 5.45 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3676.39 | nM | 5.43 |
| CHEMBL379975 | — | IC50 | = | 3875.45 | nM | 5.41 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4230.64 | nM | 5.37 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4524.56 | nM | 5.34 |
| CHEMBL399530 | — | IC50 | = | 4844.68 | nM | 5.32 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 4848.25 | nM | 5.31 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5123.17 | nM | 5.29 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 6313.59 | nM | 5.20 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 6292.01 | nM | 5.20 |
| CHEMBL176544 | — | IC50 | = | 6429.76 | nM | 5.19 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 6656.65 | nM | 5.18 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7677.12 | nM | 5.12 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 7662.33 | nM | 5.12 |