Assay Detail
Functional
CHEMBL2363783
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SANGER: Inhibition of human CAL-51 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-51 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.85 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 10.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 9.90 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.01 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.78 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.57 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.49 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.06 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.85 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.79 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.76 |
| CHEMBL9470 | SHIKONIN | — | 1 | 7.68 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.62 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.53 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.51 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.40 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.97 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.83 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.72 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.71 |
| CHEMBL585951 | — | — | 1 | 6.66 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.56 |
| CHEMBL217354 | — | — | 1 | 6.46 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.39 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.37 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.29 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.24 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL577784 | BX-795 | — | 1 | 5.91 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.76 |
| CHEMBL202721 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 0.09899 | nM | 10.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 0.1264 | nM | 9.90 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.9713 | nM | 9.01 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1.659 | nM | 8.78 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.707 | nM | 8.57 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 3.247 | nM | 8.49 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.613 | nM | 8.06 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 14.05 | nM | 7.85 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 16.39 | nM | 7.79 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 17.32 | nM | 7.76 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 20.85 | nM | 7.68 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 23.89 | nM | 7.62 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 29.74 | nM | 7.53 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 30.86 | nM | 7.51 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 40.05 | nM | 7.40 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 107.09 | nM | 6.97 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 148.55 | nM | 6.83 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 191.14 | nM | 6.72 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 196.51 | nM | 6.71 |
| CHEMBL585951 | — | IC50 | = | 219.29 | nM | 6.66 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 277.9 | nM | 6.56 |
| CHEMBL217354 | — | IC50 | = | 349.12 | nM | 6.46 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 402.69 | nM | 6.39 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 425.86 | nM | 6.37 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 514.37 | nM | 6.29 |
| CHEMBL803 | CYTARABINE | IC50 | = | 570.64 | nM | 6.24 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1083.97 | nM | 5.96 |
| CHEMBL577784 | BX-795 | IC50 | = | 1221.56 | nM | 5.91 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1748.55 | nM | 5.76 |
| CHEMBL202721 | — | IC50 | = | 1838.45 | nM | 5.74 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2166.99 | nM | 5.66 |
| CHEMBL259181 | — | IC50 | = | 2229.85 | nM | 5.65 |
| CHEMBL2363137 | — | IC50 | = | 2745.86 | nM | 5.56 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2846.15 | nM | 5.55 |
| CHEMBL1190711 | — | IC50 | = | 3023.34 | nM | 5.52 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3576.12 | nM | 5.45 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3526.71 | nM | 5.45 |
| CHEMBL472940 | — | IC50 | = | 3545.19 | nM | 5.45 |
| CHEMBL399530 | — | IC50 | = | 3663.14 | nM | 5.44 |
| CHEMBL188678 | — | IC50 | = | 4248.54 | nM | 5.37 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 4532.64 | nM | 5.34 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4710.82 | nM | 5.33 |
| CHEMBL573107 | — | IC50 | = | 4868.43 | nM | 5.31 |
| CHEMBL191384 | — | IC50 | = | 5301.88 | nM | 5.28 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5355.83 | nM | 5.27 |
| CHEMBL221137 | EMBELIN | IC50 | = | 5368.65 | nM | 5.27 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 5628.53 | nM | 5.25 |
| CHEMBL258844 | — | IC50 | = | 7628.41 | nM | 5.12 |
| CHEMBL3349342 | — | IC50 | = | 8099.73 | nM | 5.09 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 9102.51 | nM | 5.04 |