Assay Detail
Functional
CHEMBL2363785
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SANGER: Inhibition of human CAL-62 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-62 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.82 | 9.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.73 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.06 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.01 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.91 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.09 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.00 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.59 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.58 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.48 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.43 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.26 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.23 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.14 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.00 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.93 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.79 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.62 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.59 |
| CHEMBL217354 | — | — | 1 | 6.51 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.24 |
| CHEMBL3349342 | — | — | 1 | 6.17 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.15 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.10 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.07 |
| CHEMBL585951 | — | — | 1 | 6.05 |
| CHEMBL573107 | — | — | 1 | 6.05 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.03 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.89 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.88 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.1849 | nM | 9.73 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.8749 | nM | 9.06 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.9836 | nM | 9.01 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1.215 | nM | 8.91 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 8.183 | nM | 8.09 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 26.02 | nM | 7.58 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 32.79 | nM | 7.48 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 36.86 | nM | 7.43 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 55.19 | nM | 7.26 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 58.79 | nM | 7.23 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 71.59 | nM | 7.14 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 100.78 | nM | 7.00 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 116.95 | nM | 6.93 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 161.69 | nM | 6.79 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 241.85 | nM | 6.62 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 254.23 | nM | 6.59 |
| CHEMBL217354 | — | IC50 | = | 307.52 | nM | 6.51 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 571.21 | nM | 6.24 |
| CHEMBL3349342 | — | IC50 | = | 681.83 | nM | 6.17 |
| CHEMBL803 | CYTARABINE | IC50 | = | 709.83 | nM | 6.15 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 799.24 | nM | 6.10 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 851.17 | nM | 6.07 |
| CHEMBL573107 | — | IC50 | = | 881.52 | nM | 6.05 |
| CHEMBL585951 | — | IC50 | = | 892.93 | nM | 6.05 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 932.35 | nM | 6.03 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1279.99 | nM | 5.89 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1319.09 | nM | 5.88 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1522.92 | nM | 5.82 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1608.62 | nM | 5.79 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1787.29 | nM | 5.75 |
| CHEMBL2363137 | — | IC50 | = | 2653.6 | nM | 5.58 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2662.43 | nM | 5.58 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3175.41 | nM | 5.50 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 3340.45 | nM | 5.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3545.14 | nM | 5.45 |
| CHEMBL105442 | CI-1040 | IC50 | = | 4074.3 | nM | 5.39 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 4766.0 | nM | 5.32 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 5182.59 | nM | 5.29 |
| CHEMBL191384 | — | IC50 | = | 5891.99 | nM | 5.23 |
| CHEMBL202721 | — | IC50 | = | 5977.3 | nM | 5.22 |
| CHEMBL939 | GEFITINIB | IC50 | = | 7398.66 | nM | 5.13 |
| CHEMBL259181 | — | IC50 | = | 9438.61 | nM | 5.03 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 12434.41 | nM | 4.91 |
| CHEMBL1186585 | — | IC50 | = | 17939.14 | nM | 4.75 |
| CHEMBL399530 | — | IC50 | = | 19993.54 | nM | 4.70 |
| CHEMBL379975 | — | IC50 | = | 20015.94 | nM | 4.70 |
| CHEMBL135561 | — | IC50 | = | 20219.91 | nM | 4.69 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 22751.73 | nM | 4.64 |