Assay Detail
Functional
CHEMBL2363787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human CAL-85-1 cell growth in a cell viability assay.
98
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-85-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 5.70 | 9.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 9.75 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.18 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.31 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.22 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.74 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.35 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.18 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.14 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.03 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.84 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.79 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.78 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.75 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.25 |
| CHEMBL585951 | — | — | 1 | 6.05 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.04 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 5.91 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.91 |
| CHEMBL217354 | — | — | 1 | 5.84 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.82 |
| CHEMBL191384 | — | — | 1 | 5.82 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.74 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.67 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 1 | 5.64 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.58 |
| CHEMBL1190711 | — | — | 1 | 5.48 |
| CHEMBL3349342 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 0.1777 | nM | 9.75 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6617 | nM | 9.18 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.904 | nM | 8.31 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 5.524 | nM | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.035 | nM | 8.22 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 11.92 | nM | 7.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 18.32 | nM | 7.74 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 44.52 | nM | 7.35 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 65.88 | nM | 7.18 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 72.66 | nM | 7.14 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 92.48 | nM | 7.03 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 144.63 | nM | 6.84 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 160.73 | nM | 6.79 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 167.38 | nM | 6.78 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 179.27 | nM | 6.75 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 247.05 | nM | 6.61 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 565.18 | nM | 6.25 |
| CHEMBL585951 | — | IC50 | = | 880.89 | nM | 6.05 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 907.0 | nM | 6.04 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 1231.38 | nM | 5.91 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1245.89 | nM | 5.91 |
| CHEMBL217354 | — | IC50 | = | 1432.7 | nM | 5.84 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1525.99 | nM | 5.82 |
| CHEMBL191384 | — | IC50 | = | 1503.94 | nM | 5.82 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 1804.9 | nM | 5.74 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2159.44 | nM | 5.67 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2281.12 | nM | 5.64 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2661.61 | nM | 5.58 |
| CHEMBL1190711 | — | IC50 | = | 3333.31 | nM | 5.48 |
| CHEMBL3349342 | — | IC50 | = | 3569.14 | nM | 5.45 |
| CHEMBL2363137 | — | IC50 | = | 3610.94 | nM | 5.44 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4024.61 | nM | 5.39 |
| CHEMBL259181 | — | IC50 | = | 4452.02 | nM | 5.35 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 4543.95 | nM | 5.34 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 4794.2 | nM | 5.32 |
| CHEMBL135561 | — | IC50 | = | 5915.73 | nM | 5.23 |
| CHEMBL258844 | — | IC50 | = | 5953.09 | nM | 5.22 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6079.95 | nM | 5.22 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 6609.36 | nM | 5.18 |
| CHEMBL472940 | — | IC50 | = | 7372.85 | nM | 5.13 |
| CHEMBL512504 | — | IC50 | = | 7455.87 | nM | 5.13 |
| CHEMBL221137 | EMBELIN | IC50 | = | 7810.52 | nM | 5.11 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7923.68 | nM | 5.10 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 9873.83 | nM | 5.01 |
| CHEMBL591429 | PAC-1 | IC50 | = | 10274.02 | nM | 4.99 |
| CHEMBL577784 | BX-795 | IC50 | = | 10761.8 | nM | 4.97 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10940.48 | nM | 4.96 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 13439.94 | nM | 4.87 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 14425.78 | nM | 4.84 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 16583.71 | nM | 4.78 |