Assay Detail
Functional
CHEMBL2363790
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SANGER: Inhibition of human TE-12 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-12 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.57 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.37 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.97 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.75 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.73 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.59 |
| CHEMBL514499 | GW843682X | — | 1 | 7.56 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.48 |
| CHEMBL300389 | — | — | 1 | 7.31 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.26 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.25 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.09 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.85 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.80 |
| CHEMBL401930 | — | — | 1 | 6.75 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.72 |
| CHEMBL379300 | A-443654 | — | 1 | 6.71 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.66 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.58 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.49 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.48 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.45 |
| CHEMBL197603 | — | — | 1 | 6.39 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.36 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 6.31 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.30 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.29 |
| CHEMBL1190711 | — | — | 1 | 6.28 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.28 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4.25 | nM | 8.37 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 5.474 | nM | 8.26 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 10.59 | nM | 7.97 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 17.75 | nM | 7.75 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 18.61 | nM | 7.73 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL514499 | GW843682X | IC50 | = | 27.3 | nM | 7.56 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 33.09 | nM | 7.48 |
| CHEMBL300389 | — | IC50 | = | 48.55 | nM | 7.31 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 54.41 | nM | 7.26 |
| CHEMBL513909 | BI-2536 | IC50 | = | 56.13 | nM | 7.25 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 81.06 | nM | 7.09 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 140.93 | nM | 6.85 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 159.62 | nM | 6.80 |
| CHEMBL401930 | — | IC50 | = | 176.09 | nM | 6.75 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 189.83 | nM | 6.72 |
| CHEMBL379300 | A-443654 | IC50 | = | 193.83 | nM | 6.71 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 220.78 | nM | 6.66 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 265.25 | nM | 6.58 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 326.8 | nM | 6.49 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 333.17 | nM | 6.48 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 358.41 | nM | 6.45 |
| CHEMBL197603 | — | IC50 | = | 404.08 | nM | 6.39 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 434.26 | nM | 6.36 |
| CHEMBL554 | LAPATINIB | IC50 | = | 490.57 | nM | 6.31 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 496.53 | nM | 6.30 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 510.68 | nM | 6.29 |
| CHEMBL1190711 | — | IC50 | = | 531.23 | nM | 6.28 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 521.62 | nM | 6.28 |
| CHEMBL509032 | TAE-684 | IC50 | = | 533.49 | nM | 6.27 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 557.35 | nM | 6.25 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 611.99 | nM | 6.21 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 653.94 | nM | 6.18 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 712.7 | nM | 6.15 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 700.72 | nM | 6.15 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 718.85 | nM | 6.14 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 764.86 | nM | 6.12 |
| CHEMBL535 | SUNITINIB | IC50 | = | 804.55 | nM | 6.09 |
| CHEMBL939 | GEFITINIB | IC50 | = | 821.11 | nM | 6.09 |
| CHEMBL213100 | — | IC50 | = | 888.31 | nM | 6.05 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1133.33 | nM | 5.95 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1173.66 | nM | 5.93 |
| CHEMBL585951 | — | IC50 | = | 1210.31 | nM | 5.92 |
| CHEMBL2144069 | — | IC50 | = | 1314.17 | nM | 5.88 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1406.01 | nM | 5.85 |
| CHEMBL191384 | — | IC50 | = | 1404.69 | nM | 5.85 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1804.14 | nM | 5.74 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1991.28 | nM | 5.70 |
| CHEMBL379975 | — | IC50 | = | 2094.14 | nM | 5.68 |
| CHEMBL1643959 | — | IC50 | = | 2354.01 | nM | 5.63 |