Assay Detail
Functional
CHEMBL2363840
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SANGER: Inhibition of human CHL-1 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHL-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.99 | 10.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.49 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.02 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.01 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.55 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.21 |
| CHEMBL217354 | — | — | 1 | 7.92 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.92 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.90 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.87 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.81 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.74 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.65 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.42 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.31 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.93 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.78 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.74 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.68 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.68 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.65 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.49 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 6.42 |
| CHEMBL585951 | — | — | 1 | 6.31 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.28 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.26 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.24 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.03241 | nM | 10.49 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.9583 | nM | 9.02 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.979 | nM | 9.01 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2.811 | nM | 8.55 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 4.595 | nM | 8.34 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 5.856 | nM | 8.23 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.091 | nM | 8.21 |
| CHEMBL217354 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 12.49 | nM | 7.90 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 13.48 | nM | 7.87 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 15.45 | nM | 7.81 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 18.39 | nM | 7.74 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 22.51 | nM | 7.65 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 37.73 | nM | 7.42 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 41.69 | nM | 7.38 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 48.57 | nM | 7.31 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 116.15 | nM | 6.93 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 167.8 | nM | 6.78 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 181.51 | nM | 6.74 |
| CHEMBL939 | GEFITINIB | IC50 | = | 208.51 | nM | 6.68 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 209.51 | nM | 6.68 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 225.16 | nM | 6.65 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 327.03 | nM | 6.49 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 378.65 | nM | 6.42 |
| CHEMBL585951 | — | IC50 | = | 490.14 | nM | 6.31 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 525.51 | nM | 6.28 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 554.65 | nM | 6.26 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 574.63 | nM | 6.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 642.08 | nM | 6.19 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 731.54 | nM | 6.14 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 805.46 | nM | 6.09 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 882.9 | nM | 6.05 |
| CHEMBL379975 | — | IC50 | = | 1052.92 | nM | 5.98 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1043.16 | nM | 5.98 |
| CHEMBL3349342 | — | IC50 | = | 1184.04 | nM | 5.93 |
| CHEMBL188678 | — | IC50 | = | 1213.68 | nM | 5.92 |
| CHEMBL577784 | BX-795 | IC50 | = | 1923.79 | nM | 5.72 |
| CHEMBL573107 | — | IC50 | = | 1957.92 | nM | 5.71 |
| CHEMBL2363137 | — | IC50 | = | 2177.79 | nM | 5.66 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2807.85 | nM | 5.55 |
| CHEMBL202721 | — | IC50 | = | 3422.49 | nM | 5.47 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3348.83 | nM | 5.47 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 3496.65 | nM | 5.46 |
| CHEMBL189584 | PD-173074 | IC50 | = | 3657.99 | nM | 5.44 |
| CHEMBL1190711 | — | IC50 | = | 4046.0 | nM | 5.39 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 4189.61 | nM | 5.38 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4321.69 | nM | 5.36 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 4719.89 | nM | 5.33 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4695.48 | nM | 5.33 |