Assay Detail
Functional
CHEMBL2363847
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SANGER: Inhibition of human COLO-668 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO-668 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.46 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 10.66 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.57 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.71 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.65 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.54 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.41 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.40 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.10 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.07 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.63 |
| CHEMBL300389 | — | — | 1 | 6.63 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.53 |
| CHEMBL514499 | GW843682X | — | 1 | 6.47 |
| CHEMBL585951 | — | — | 1 | 6.42 |
| CHEMBL379300 | A-443654 | — | 1 | 6.39 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.39 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.37 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.34 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.30 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.25 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.15 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.09 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.07 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.04 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.95 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.93 |
| CHEMBL401930 | — | — | 1 | 5.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.88 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 0.02177 | nM | 10.66 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 2.66 | nM | 8.57 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 7.545 | nM | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 19.68 | nM | 7.71 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 22.32 | nM | 7.65 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 38.87 | nM | 7.41 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 39.75 | nM | 7.40 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 79.84 | nM | 7.10 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 84.47 | nM | 7.07 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 236.75 | nM | 6.63 |
| CHEMBL300389 | — | IC50 | = | 236.16 | nM | 6.63 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 294.29 | nM | 6.53 |
| CHEMBL514499 | GW843682X | IC50 | = | 336.11 | nM | 6.47 |
| CHEMBL585951 | — | IC50 | = | 375.85 | nM | 6.42 |
| CHEMBL379300 | A-443654 | IC50 | = | 405.44 | nM | 6.39 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 403.57 | nM | 6.39 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 427.37 | nM | 6.37 |
| CHEMBL513909 | BI-2536 | IC50 | = | 456.68 | nM | 6.34 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 498.56 | nM | 6.30 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 562.6 | nM | 6.25 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 706.1 | nM | 6.15 |
| CHEMBL803 | CYTARABINE | IC50 | = | 809.16 | nM | 6.09 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 846.66 | nM | 6.07 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 910.87 | nM | 6.04 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1122.32 | nM | 5.95 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1164.9 | nM | 5.93 |
| CHEMBL401930 | — | IC50 | = | 1191.62 | nM | 5.92 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1330.56 | nM | 5.88 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1664.31 | nM | 5.78 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2299.73 | nM | 5.64 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 2432.0 | nM | 5.61 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 2504.58 | nM | 5.60 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 2826.95 | nM | 5.55 |
| CHEMBL591429 | PAC-1 | IC50 | = | 3202.75 | nM | 5.49 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 3297.72 | nM | 5.48 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 3392.2 | nM | 5.47 |
| CHEMBL191384 | — | IC50 | = | 4468.68 | nM | 5.35 |
| CHEMBL2363137 | — | IC50 | = | 4484.82 | nM | 5.35 |
| CHEMBL217354 | — | IC50 | = | 5099.78 | nM | 5.29 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 5402.21 | nM | 5.27 |
| CHEMBL554 | LAPATINIB | IC50 | = | 5726.67 | nM | 5.24 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5713.2 | nM | 5.24 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 6196.13 | nM | 5.21 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 6843.87 | nM | 5.17 |
| CHEMBL939 | GEFITINIB | IC50 | = | 7439.67 | nM | 5.13 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 8418.7 | nM | 5.08 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 8277.86 | nM | 5.08 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 8594.91 | nM | 5.07 |
| CHEMBL379975 | — | IC50 | = | 10379.42 | nM | 4.98 |