Assay Detail
Functional
CHEMBL2363849
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SANGER: Inhibition of human COLO-679 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO-679 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.74 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.96 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.40 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.74 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 8.30 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.00 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.80 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.51 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.04 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.95 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.91 |
| CHEMBL3349342 | — | — | 1 | 6.82 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.79 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.74 |
| CHEMBL217354 | — | — | 1 | 6.63 |
| CHEMBL585951 | — | — | 1 | 6.60 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.49 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.47 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.42 |
| CHEMBL477989 | SB590885 | — | 1 | 6.41 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.21 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.20 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 6.09 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 6.01 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 5.96 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.93 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 5.86 |
| CHEMBL2363137 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.1093 | nM | 9.96 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.3939 | nM | 9.40 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.832 | nM | 8.74 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4.985 | nM | 8.30 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 10.07 | nM | 8.00 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 10.01 | nM | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 14.14 | nM | 7.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.97 | nM | 7.80 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 31.07 | nM | 7.51 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 90.25 | nM | 7.04 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 90.91 | nM | 7.04 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 112.11 | nM | 6.95 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 122.15 | nM | 6.91 |
| CHEMBL3349342 | — | IC50 | = | 152.55 | nM | 6.82 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 163.03 | nM | 6.79 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 184.01 | nM | 6.74 |
| CHEMBL217354 | — | IC50 | = | 233.62 | nM | 6.63 |
| CHEMBL585951 | — | IC50 | = | 249.52 | nM | 6.60 |
| CHEMBL105442 | CI-1040 | IC50 | = | 327.2 | nM | 6.49 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 341.19 | nM | 6.47 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 382.55 | nM | 6.42 |
| CHEMBL477989 | SB590885 | IC50 | = | 386.41 | nM | 6.41 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 621.72 | nM | 6.21 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 629.46 | nM | 6.20 |
| CHEMBL591429 | PAC-1 | IC50 | = | 803.34 | nM | 6.09 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 985.06 | nM | 6.01 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 1104.64 | nM | 5.96 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1169.45 | nM | 5.93 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 1381.5 | nM | 5.86 |
| CHEMBL2363137 | — | IC50 | = | 2400.26 | nM | 5.62 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 2586.05 | nM | 5.59 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2661.72 | nM | 5.58 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2612.33 | nM | 5.58 |
| CHEMBL259181 | — | IC50 | = | 2657.88 | nM | 5.58 |
| CHEMBL135561 | — | IC50 | = | 4075.55 | nM | 5.39 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4197.91 | nM | 5.38 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4166.29 | nM | 5.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4791.52 | nM | 5.32 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 5300.11 | nM | 5.28 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5415.81 | nM | 5.27 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 5889.48 | nM | 5.23 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 6002.55 | nM | 5.22 |
| CHEMBL379975 | — | IC50 | = | 7109.59 | nM | 5.15 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 7986.71 | nM | 5.10 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 10428.48 | nM | 4.98 |
| CHEMBL188678 | — | IC50 | = | 11945.99 | nM | 4.92 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 12815.65 | nM | 4.89 |
| CHEMBL1190711 | — | IC50 | = | 13656.57 | nM | 4.87 |
| CHEMBL573107 | — | IC50 | = | 15101.33 | nM | 4.82 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 15501.05 | nM | 4.81 |