Assay Detail
Binding
CHEMBL2377927
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Displacement of [3H]-5-HT from calf 5HT1D receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | — | 1 | 7.70 |
| CHEMBL2376490 | — | — | 1 | 7.48 |
| CHEMBL2376484 | — | — | 1 | 7.46 |
| CHEMBL2376482 | — | — | 1 | 6.89 |
| CHEMBL2376483 | — | — | 1 | 6.80 |
| CHEMBL2376487 | — | — | 1 | 6.51 |
| CHEMBL2376491 | — | — | 1 | 6.41 |
| CHEMBL1550957 | — | — | 1 | 5.92 |
| CHEMBL414668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18785 | RU-24969 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2376490 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2376484 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2376482 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2376483 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2376487 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL2376491 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1550957 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL414668 | — | IC50 | > | 1000.0 | nM | - |