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Assay Detail

CHEMBL2378057

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as decrease in cell survival after 72 hrs by MTT assay
36
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Phenylpropiophenone derivatives as potential anticancer agents: synthesis, biological evaluation and quantitative structure-activity relationship study.
Ivković BM, Nikolic K, Ilić BB, Žižak ŽS, Novaković RB, Čudina OA, Vladimirov SM.
Eur J Med Chem (2013) 63 : 239 -255
PubMed 23501110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.91 5.52
Activity 12 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2375427 3 5.52
CHEMBL2375422 3 5.17
CHEMBL2375425 3 5.05
CHEMBL2375419 3 5.05
CHEMBL2375421 3 4.95
CHEMBL2375420 3 4.83
CHEMBL2375424 3 4.79
CHEMBL2375423 3 4.79
CHEMBL2375418 3 4.74
CHEMBL476598 3 4.69
CHEMBL2375426 3 4.66
CHEMBL1963387 3 4.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2375427 IC50 = 3000.0 nM 5.52
CHEMBL2375427 IC50 = 2999.99 nM 5.52
CHEMBL2375422 IC50 = 6780.0 nM 5.17
CHEMBL2375422 IC50 = 6780.0 nM 5.17
CHEMBL2375419 IC50 = 8900.0 nM 5.05
CHEMBL2375425 IC50 = 8900.0 nM 5.05
CHEMBL2375419 IC50 = 8900.0 nM 5.05
CHEMBL2375425 IC50 = 8900.0 nM 5.05
CHEMBL2375421 IC50 = 11200.05 nM 4.95
CHEMBL2375421 IC50 = 11200.0 nM 4.95
CHEMBL2375420 IC50 = 14700.09 nM 4.83
CHEMBL2375420 IC50 = 14700.0 nM 4.83
CHEMBL2375423 IC50 = 16419.88 nM 4.79
CHEMBL2375424 IC50 = 16100.15 nM 4.79
CHEMBL2375424 IC50 = 16100.0 nM 4.79
CHEMBL2375423 IC50 = 16420.0 nM 4.79
CHEMBL2375418 IC50 = 18100.0 nM 4.74
CHEMBL2375418 IC50 = 18140.11 nM 4.74
CHEMBL476598 IC50 = 20600.13 nM 4.69
CHEMBL476598 IC50 = 20600.0 nM 4.69
CHEMBL2375426 IC50 = 21700.01 nM 4.66
CHEMBL2375426 IC50 = 21700.0 nM 4.66
CHEMBL1963387 IC50 = 22600.0 nM 4.65
CHEMBL1963387 IC50 = 22600.08 nM 4.65
CHEMBL2375418 Activity - -
CHEMBL2375419 Activity - -
CHEMBL1963387 Activity - -
CHEMBL2375420 Activity - -
CHEMBL476598 Activity - -
CHEMBL2375421 Activity - -
CHEMBL2375422 Activity - -
CHEMBL2375423 Activity - -
CHEMBL2375424 Activity - -
CHEMBL2375425 Activity - -
CHEMBL2375426 Activity - -
CHEMBL2375427 Activity - -