Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2378059

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human IKKbeta using GST-IkappaBalpha as substrate
ChEMBL ↗
171
Total Activities
171
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.
Huang JJ, Wu XW, Jia JM, Guo XK, Xue X, Jiang ZY, Zhang SL, Zhang XJ, Sun HP, You QD.
Eur J Med Chem (2013) 63 : 269 -278
PubMed 23501112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 171 7.10 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL250105 — — 1 8.60
CHEMBL182407 — — 1 8.52
CHEMBL249280 — — 1 8.52
CHEMBL183703 — — 1 8.40
CHEMBL493974 — — 1 8.30
CHEMBL181495 — — 1 8.30
CHEMBL181334 — — 1 8.30
CHEMBL182749 — — 1 8.22
CHEMBL521643 — — 1 8.22
CHEMBL249482 — — 1 8.15
CHEMBL549478 — — 1 8.15
CHEMBL558491 — — 1 8.15
CHEMBL1831200 — — 1 8.10
CHEMBL249104 — — 1 8.10
CHEMBL1761516 — — 1 8.10
CHEMBL551773 — — 1 8.10
CHEMBL2375673 — — 1 8.07
CHEMBL400077 — — 1 8.07
CHEMBL361233 — — 1 8.04
CHEMBL1831202 — — 1 8.04
CHEMBL493940 — — 1 7.96
CHEMBL562720 — — 1 7.96
CHEMBL390201 — — 1 7.96
CHEMBL131693 — — 1 7.96
CHEMBL361841 — — 1 7.92
CHEMBL562971 — — 1 7.92
CHEMBL1761512 — — 1 7.90
CHEMBL398253 — — 1 7.89
CHEMBL404609 — — 1 7.89
CHEMBL249886 — — 1 7.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL250105 — IC50 = 2.512 nM 8.60
CHEMBL249280 — IC50 = 3.02 nM 8.52
CHEMBL182407 — IC50 = 3.02 nM 8.52
CHEMBL183703 — IC50 = 3.981 nM 8.40
CHEMBL181495 — IC50 = 5.012 nM 8.30
CHEMBL181334 — IC50 = 5.012 nM 8.30
CHEMBL493974 — IC50 = 5.012 nM 8.30
CHEMBL521643 — IC50 = 6.026 nM 8.22
CHEMBL182749 — IC50 = 6.026 nM 8.22
CHEMBL249482 — IC50 = 7.079 nM 8.15
CHEMBL558491 — IC50 = 7.079 nM 8.15
CHEMBL549478 — IC50 = 7.079 nM 8.15
CHEMBL1831200 — IC50 = 7.943 nM 8.10
CHEMBL551773 — IC50 = 7.943 nM 8.10
CHEMBL1761516 — IC50 = 7.943 nM 8.10
CHEMBL249104 — IC50 = 7.943 nM 8.10
CHEMBL400077 — IC50 = 8.511 nM 8.07
CHEMBL2375673 — IC50 = 8.511 nM 8.07
CHEMBL1831202 — IC50 = 9.12 nM 8.04
CHEMBL361233 — IC50 = 9.12 nM 8.04
CHEMBL390201 — IC50 = 10.96 nM 7.96
CHEMBL562720 — IC50 = 10.96 nM 7.96
CHEMBL131693 — IC50 = 10.96 nM 7.96
CHEMBL493940 — IC50 = 10.96 nM 7.96
CHEMBL361841 — IC50 = 12.02 nM 7.92
CHEMBL562971 — IC50 = 12.02 nM 7.92
CHEMBL1761512 — IC50 = 12.59 nM 7.90
CHEMBL404609 — IC50 = 12.88 nM 7.89
CHEMBL249886 — IC50 = 12.88 nM 7.89
CHEMBL398253 — IC50 = 12.88 nM 7.89
CHEMBL399689 — IC50 = 14.13 nM 7.85
CHEMBL181756 — IC50 = 14.13 nM 7.85
CHEMBL552183 — IC50 = 14.13 nM 7.85
CHEMBL182173 — IC50 = 14.13 nM 7.85
CHEMBL181434 — IC50 = 15.14 nM 7.82
CHEMBL182358 — IC50 = 15.14 nM 7.82
CHEMBL360337 — IC50 = 15.14 nM 7.82
CHEMBL2375543 — IC50 = 15.14 nM 7.82
CHEMBL2375676 — IC50 = 15.14 nM 7.82
CHEMBL2375677 — IC50 = 15.14 nM 7.82
CHEMBL520473 — IC50 = 15.85 nM 7.80
CHEMBL522014 — IC50 = 15.85 nM 7.80
CHEMBL231530 — IC50 = 18.2 nM 7.74
CHEMBL230184 — IC50 = 18.2 nM 7.74
CHEMBL249481 — IC50 = 18.2 nM 7.74
CHEMBL399688 — IC50 = 19.05 nM 7.72
CHEMBL483165 — IC50 = 19.95 nM 7.70
CHEMBL361548 — IC50 = 19.95 nM 7.70
CHEMBL483557 — IC50 = 19.95 nM 7.70
CHEMBL1761513 — IC50 = 19.95 nM 7.70