Assay Detail
Functional
CHEMBL2378258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against antimony-resistant Leishmania amazonensis MHOM/BR/1989/BA199 promastigote infected in Swiss mouse peritoneal macrophages after 72 hrs
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent naphthoquinones against antimony-sensitive and -resistant Leishmania parasites: synthesis of novel α- and nor-α-lapachone-based 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.24 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454129 | — | — | 1 | 5.99 |
| CHEMBL2375479 | — | — | 1 | 5.94 |
| CHEMBL2375477 | — | — | 1 | 5.92 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.86 |
| CHEMBL2375552 | — | — | 1 | 5.86 |
| CHEMBL518583 | — | — | 1 | 5.81 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | — | 1 | 5.80 |
| CHEMBL2375473 | — | — | 1 | 5.72 |
| CHEMBL2375474 | — | — | 1 | 5.71 |
| CHEMBL2023280 | — | — | 1 | 5.60 |
| CHEMBL2023279 | — | — | 1 | 5.53 |
| CHEMBL2023281 | — | — | 1 | 5.46 |
| CHEMBL2375478 | — | — | 1 | 5.37 |
| CHEMBL2023277 | — | — | 1 | 5.36 |
| CHEMBL2375551 | — | — | 1 | 5.14 |
| CHEMBL2022335 | — | — | 1 | 5.10 |
| CHEMBL2375475 | — | — | 1 | 5.09 |
| CHEMBL2022339 | — | — | 1 | 4.86 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 4.82 |
| CHEMBL2375476 | — | — | 1 | 4.67 |
| CHEMBL2022340 | — | — | 1 | 4.67 |
| CHEMBL2022336 | — | — | 1 | 4.61 |
| CHEMBL2375550 | — | — | 1 | 4.57 |
| CHEMBL2375360 | — | — | 1 | 4.39 |
| CHEMBL2022337 | — | — | 1 | 4.30 |
| CHEMBL15193 | LAPACHOL | — | 1 | 4.20 |
| CHEMBL374724 | — | — | 1 | - |
| CHEMBL2022338 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454129 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2375479 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL2375477 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2375552 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL518583 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2375473 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2375474 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL2023280 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL2023279 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL2023281 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL2375478 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL2023277 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL2375551 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL2022335 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL2375475 | — | IC50 | = | 8040.0 | nM | 5.09 |
| CHEMBL2022339 | — | IC50 | = | 13790.0 | nM | 4.86 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 15150.0 | nM | 4.82 |
| CHEMBL2375476 | — | IC50 | = | 21550.0 | nM | 4.67 |
| CHEMBL2022340 | — | IC50 | = | 21320.0 | nM | 4.67 |
| CHEMBL2022336 | — | IC50 | = | 24540.0 | nM | 4.61 |
| CHEMBL2375550 | — | IC50 | = | 27040.0 | nM | 4.57 |
| CHEMBL2375360 | — | IC50 | = | 40250.0 | nM | 4.39 |
| CHEMBL2022337 | — | IC50 | = | 50150.0 | nM | 4.30 |
| CHEMBL15193 | LAPACHOL | IC50 | = | 63280.0 | nM | 4.20 |
| CHEMBL374724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2022338 | — | IC50 | > | 100000.0 | nM | - |