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Assay Detail

CHEMBL2378323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human recombinant DAAO at 395 nm spectral modification by spectrophotometric analysis in presence of FAD
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D-amino-acid oxidase (CHEMBL5485)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH.
J Med Chem (2013) 56 : 3710 -3724
PubMed 23631755 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 5.40 5.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2375520 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2375520 Kd = 4000.0 nM 5.40