Assay Detail
Binding
CHEMBL2378382
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Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serine
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.61 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2375520 | — | — | 1 | 8.77 |
| CHEMBL507614 | — | — | 1 | 8.46 |
| CHEMBL453239 | — | — | 1 | 8.14 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | — | 1 | 7.89 |
| CHEMBL2375519 | — | — | 1 | 6.72 |
| CHEMBL541 | BENZOIC ACID | -1.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2375520 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL507614 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL453239 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL150372 | 3-HYDROXYCOUMARIN | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2375519 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL541 | BENZOIC ACID | Ki | = | 2000.0 | nM | 5.70 |