Assay Detail
Binding
CHEMBL2378944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological activities of Nilotinib derivates as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.66 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 9.48 |
| CHEMBL2375971 | — | — | 1 | 9.28 |
| CHEMBL2375973 | — | — | 1 | 8.83 |
| CHEMBL2375972 | — | — | 1 | 8.63 |
| CHEMBL2375892 | — | — | 1 | 8.49 |
| CHEMBL2375900 | — | — | 1 | 8.42 |
| CHEMBL2375889 | — | — | 1 | 8.32 |
| CHEMBL2375891 | — | — | 1 | 8.32 |
| CHEMBL2375977 | — | — | 1 | 8.20 |
| CHEMBL2375895 | — | — | 1 | 7.46 |
| CHEMBL2375976 | — | — | 1 | 7.20 |
| CHEMBL2375901 | — | — | 1 | 6.53 |
| CHEMBL2375974 | — | — | 1 | 6.46 |
| CHEMBL2375975 | — | — | 1 | 5.96 |
| CHEMBL2375898 | — | — | 1 | 5.56 |
| CHEMBL2375890 | — | — | 1 | 5.38 |
| CHEMBL2375899 | — | — | 1 | - |
| CHEMBL2375893 | — | — | 1 | - |
| CHEMBL2375894 | — | — | 1 | - |
| CHEMBL2375896 | — | — | 1 | - |
| CHEMBL2375897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL2375971 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL2375973 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL2375972 | — | IC50 | = | 2.34 | nM | 8.63 |
| CHEMBL2375892 | — | IC50 | = | 3.21 | nM | 8.49 |
| CHEMBL2375900 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL2375889 | — | IC50 | = | 4.73 | nM | 8.32 |
| CHEMBL2375891 | — | IC50 | = | 4.79 | nM | 8.32 |
| CHEMBL2375977 | — | IC50 | = | 6.34 | nM | 8.20 |
| CHEMBL2375895 | — | IC50 | = | 34.77 | nM | 7.46 |
| CHEMBL2375976 | — | IC50 | = | 63.31 | nM | 7.20 |
| CHEMBL2375901 | — | IC50 | = | 294.34 | nM | 6.53 |
| CHEMBL2375974 | — | IC50 | = | 350.08 | nM | 6.46 |
| CHEMBL2375975 | — | IC50 | = | 1110.42 | nM | 5.96 |
| CHEMBL2375898 | — | IC50 | = | 2754.9 | nM | 5.56 |
| CHEMBL2375890 | — | IC50 | = | 4125.31 | nM | 5.38 |
| CHEMBL2375899 | — | IC50 | - | — | - | |
| CHEMBL2375893 | — | IC50 | - | — | - | |
| CHEMBL2375894 | — | IC50 | - | — | - | |
| CHEMBL2375896 | — | IC50 | - | — | - | |
| CHEMBL2375897 | — | IC50 | - | — | - |