Assay Detail
Functional
CHEMBL2379102
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Antiproliferative activity against human HT-29 cells after 24 hrs by MTS assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and antiproliferative properties of some new 5-substituted-2-iminobenzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.23 | 7.61 |
| IC50 | 2 | 8.87 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377273 | — | — | 1 | 9.19 |
| CHEMBL2377274 | — | — | 1 | 8.55 |
| CHEMBL2377275 | — | — | 1 | 7.61 |
| CHEMBL2377272 | — | — | 1 | 7.33 |
| CHEMBL2377271 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377273 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL2377274 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL2377275 | — | EC50 | = | 24.5 | nM | 7.61 |
| CHEMBL2377272 | — | EC50 | = | 46.7 | nM | 7.33 |
| CHEMBL2377271 | — | EC50 | = | 177.0 | nM | 6.75 |