Assay Detail
Functional
CHEMBL2379120
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Cytotoxicity against human chemo-resistant T24 cells by WST assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.63 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72974 | — | — | 1 | 9.77 |
| CHEMBL419083 | — | — | 1 | 9.49 |
| CHEMBL306280 | DIFLOMOTECAN | 2.0 | 1 | 9.40 |
| CHEMBL306721 | — | — | 1 | 8.80 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | — | 1 | 8.48 |
| CHEMBL306796 | — | — | 1 | 8.35 |
| CHEMBL74863 | — | — | 1 | 7.66 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72974 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL419083 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL306280 | DIFLOMOTECAN | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL306721 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL74190 | HOMOCAMPTOTHECIN | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL306796 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL74863 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 88.0 | nM | 7.06 |