Assay Detail
Binding
CHEMBL2379203
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Binding affinity to human biotinylated telomeric G-quadruplex 5'-d(GGG[TTAGGG]3)-3' DNA by surface plasmon resonance analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.82 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2376049 | — | — | 1 | 6.64 |
| CHEMBL2376051 | — | — | 1 | 6.56 |
| CHEMBL2376048 | — | — | 1 | 6.52 |
| CHEMBL2376052 | — | — | 1 | 6.42 |
| CHEMBL2376047 | — | — | 1 | 5.96 |
| CHEMBL2376046 | — | — | 1 | 5.83 |
| CHEMBL2376043 | — | — | 1 | 5.79 |
| CHEMBL2376065 | — | — | 1 | 5.56 |
| CHEMBL2376050 | — | — | 1 | 5.51 |
| CHEMBL2376061 | — | — | 1 | 5.47 |
| CHEMBL2376062 | — | — | 1 | 5.08 |
| CHEMBL219728 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2376049 | — | Kd | = | 227.0 | nM | 6.64 |
| CHEMBL2376051 | — | Kd | = | 276.0 | nM | 6.56 |
| CHEMBL2376048 | — | Kd | = | 302.0 | nM | 6.52 |
| CHEMBL2376052 | — | Kd | = | 379.0 | nM | 6.42 |
| CHEMBL2376047 | — | Kd | = | 1110.0 | nM | 5.96 |
| CHEMBL2376046 | — | Kd | = | 1480.0 | nM | 5.83 |
| CHEMBL2376043 | — | Kd | = | 1610.0 | nM | 5.79 |
| CHEMBL2376065 | — | Kd | = | 2750.0 | nM | 5.56 |
| CHEMBL2376050 | — | Kd | = | 3060.0 | nM | 5.51 |
| CHEMBL2376061 | — | Kd | = | 3360.0 | nM | 5.47 |
| CHEMBL2376062 | — | Kd | = | 8340.0 | nM | 5.08 |
| CHEMBL219728 | — | Kd | = | 28000.0 | nM | 4.55 |